Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | GBA2 | Q9HCG7 | 9/20 | 0.34 |
| ▸ | GBA1 | P04062 | 5/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21016209 | 0.77 | GNAI3 (0.49) | ALDH1A1L3MBTL1TDP1SMN1; SMN2HTR1A | |
| SCHEMBL22374866 | 0.77 | TDP1 (0.37) | ALDH1A1L3MBTL1POLBTDP1SMN1; SMN2 | |
| SCHEMBL26705552 | 0.76 | L3MBTL1 (0.47) | ALDH1A1L3MBTL1POLBTDP1GAA | |
| SCHEMBL15934102 | 0.76 | GAA (0.46) | L3MBTL1POLBTDP1GAASMN1; SMN2 | |
| SCHEMBL26445138 | 0.75 | L3MBTL1 (0.45) | ALDH1A1L3MBTL1POLBTDP1 | |
| SCHEMBL26445170 | 0.75 | L3MBTL1 (0.45) | ALDH1A1L3MBTL1POLBTDP1 | |
| SCHEMBL22374861 | 0.74 | BDKRB1 (0.35) | ALDH1A1L3MBTL1POLBTDP1SMN1; SMN2 | |
| SCHEMBL20965472 | 0.74 | ATM (0.45) | ALDH1A1L3MBTL1TDP1SMN1; SMN2HTR1A | |
| SCHEMBL24675781 | 0.72 | GNAI3 (0.58) | ALDH1A1L3MBTL1TDP1SMN1; SMN2CYP2C19 | |
| SCHEMBL25819361 | 0.72 | GNAI3 (0.48) | ALDH1A1L3MBTL1TDP1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A9 | DEGRADERS OF GRK2 AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |