Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 5/20 | 0.48 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.48 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24675781 | 0.91 | GNAI3 (0.58) | GNAI3GNAI1GNAO1MEN1KMT2A | |
| SCHEMBL23484812 | 0.80 | GNAI3 (0.51) | GNAI3GNAI1GNAO1MEN1KMT2A | |
| SCHEMBL27400094 | 0.78 | GNAI3 (0.42) | GNAI3GNAI1GNAO1MEN1KMT2A | |
| SCHEMBL12282233 | 0.77 | KMT2A (0.52) | GNAI3GNAI1GNAO1MEN1KMT2A | |
| SCHEMBL13964520 | 0.76 | NPC1 (0.51) | GNAI3GNAI1GNAO1MEN1KMT2A | |
| SCHEMBL12282009 | 0.76 | KDM4E (0.49) | GNAI3GNAI1GNAO1MEN1KMT2A | |
| SCHEMBL8972852 | 0.75 | GNAI3 (0.71) | GNAI3GNAI1GNAO1MEN1KMT2A | |
| SCHEMBL8972071 | 0.75 | GNAI3 (0.71) | GNAI3GNAI1GNAO1MEN1KMT2A | |
| SCHEMBL4548016 | 0.75 | GNAI3 (0.71) | GNAI3GNAI1GNAO1MEN1KMT2A | |
| SCHEMBL8972364 | 0.75 | GNAI3 (0.71) | GNAI3GNAI1GNAO1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129564-A9 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |