Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 9/20 | 0.58 |
| ▸ | GNAI1 | P63096 | 9/20 | 0.58 |
| ▸ | GNAO1 | P09471 | 8/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25819361 | 0.91 | GNAI3 (0.48) | GNAI3GNAI1GNAO1L3MBTL1MEN1 | |
| SCHEMBL23484812 | 0.86 | GNAI3 (0.51) | GNAI3GNAI1GNAO1L3MBTL1MEN1 | |
| SCHEMBL8972852 | 0.85 | GNAI3 (0.71) | GNAI3GNAI1GNAO1L3MBTL1MEN1 | |
| SCHEMBL31632756 | 0.85 | GNAI3 (0.71) | GNAI3GNAI1GNAO1L3MBTL1MEN1 | |
| SCHEMBL4548016 | 0.85 | GNAI3 (0.71) | GNAI3GNAI1GNAO1L3MBTL1MEN1 | |
| SCHEMBL3339374 | 0.85 | GNAI3 (0.71) | GNAI3GNAI1GNAO1L3MBTL1MEN1 | |
| SCHEMBL8972071 | 0.85 | GNAI3 (0.71) | GNAI3GNAI1GNAO1L3MBTL1MEN1 | |
| SCHEMBL8972364 | 0.85 | GNAI3 (0.71) | GNAI3GNAI1GNAO1L3MBTL1MEN1 | |
| SCHEMBL8972105 | 0.85 | GNAI3 (0.71) | GNAI3GNAI1GNAO1L3MBTL1MEN1 | |
| SCHEMBL8973186 | 0.85 | GNAI3 (0.71) | GNAI3GNAI1GNAO1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |