SCHEMBL2467701

SCHEMBL2467701

COC(=O)Oc1nc(-c2cc(OC)c(Cl)cc2F)c(F)c(N)c1Cl

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.36
TP53 P04637 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
HSP90AA1 P07900 3/20 0.34
HSP90AB1 P08238 3/20 0.34
SCN9A Q15858 3/20 0.34
NPC1 O15118 1/20 0.34
MAPT P10636 1/20 0.34
RAB9A P51151 1/20 0.34
POLB P06746 1/20 0.34
MAP2 P11137 1/20 0.34
ALDH1A1 P00352 2/20 0.33
KMT2A Q03164 2/20 0.33
KDM4E B2RXH2 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
MEN1 O00255 1/20 0.33
GLA P06280 1/20 0.33
CTSA P10619 3/20 0.33
GRM4 Q14833 1/20 0.32
PIM1 P11309 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2464541 0.90 HSP90AA1 (0.35) LMNATP53NPSR1HSP90AA1HSP90AB1
SCHEMBL3327065 0.83 GAA (0.39) LMNATP53NPSR1HSP90AA1HSP90AB1
SCHEMBL2464538 0.82 GRK6 (0.38) LMNATP53NPSR1HSP90AA1HSP90AB1
SCHEMBL2467937 0.81 HSP90AA1 (0.40) LMNATP53NPSR1HSP90AA1HSP90AB1
SCHEMBL2468287 0.80 MEP1B (0.36) SCN9AALDH1A1KMT2AKDM4ECTSA
SCHEMBL2465252 0.76 PYGL (0.39) LMNATP53NPSR1NPC1MAPT
SCHEMBL6983694 0.74 MAPT (0.38) LMNATP53NPSR1NPC1MAPT
SCHEMBL2462793 0.73 PDCD1LG2 (0.35) HSP90AA1HSP90AB1GRM4
SCHEMBL2468355 0.72 MAPK9 (0.36) HSP90AB1
SCHEMBL28795009 0.71 POLB (0.37) LMNATP53NPSR1HSP90AA1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2060566-B1 Poly-substituted aryls DOW AGROSCIENCES LLC (US) 2016-06-08 EP claimed
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2369929-A2 HERBICIDE-SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP disclosed
WO-2010060581-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO disclosed
EP-2191719-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-06-02 EP disclosed