Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.48 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LSS | P48449 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29868121 | 0.99 | TRPM8 (0.47) | TRPM8SERPINE1EPHX1TRPV1ALDH1A1 | |
| SCHEMBL24677538 | 0.89 | CYP3A4 (0.47) | TRPM8SERPINE1ALDH1A1CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL29868258 | 0.88 | CYP3A4 (0.47) | TRPM8SERPINE1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL15133430 | 0.87 | ALDH1A1 (0.55) | TRPM8SERPINE1EPHX1TRPV1ALDH1A1 | |
| SCHEMBL31448505 | 0.87 | ALDH1A1 (0.55) | TRPM8SERPINE1EPHX1TRPV1ALDH1A1 | |
| SCHEMBL24677403 | 0.86 | TRPM8 (0.50) | TRPM8SERPINE1EPHX1TRPV1ALDH1A1 | |
| SCHEMBL24677412 | 0.86 | TRPM8 (0.50) | TRPM8SERPINE1EPHX1TRPV1ALDH1A1 | |
| SCHEMBL4813136 | 0.85 | MC4R (0.52) | TRPM8SERPINE1EPHX1ALDH1A1CYP3A4 | |
| SCHEMBL4886347 | 0.85 | SERPINE1 (0.59) | TRPM8SERPINE1EPHX1TRPV1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL29868018 | 0.85 | TRPM8 (0.49) | TRPM8SERPINE1EPHX1TRPV1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022178030-A1 | TRPM8 AGONISTS AS COOLING AGENTS AND FOR THE TREATMENT OF DISEASE | Concentric Analgesics, Inc. (US) | 2022-08-25 | — | — | WO | disclosed |