SCHEMBL24677984

SCHEMBL24677984

COc1ccc(O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c(F)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.39
KIF11 P52732 2/20 0.39
MAPT P10636 2/20 0.39
KMT2A Q03164 3/20 0.37
GAA P10253 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
MAPK1 P28482 2/20 0.37
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
CA14 Q9ULX7 1/20 0.36
MEN1 O00255 2/20 0.36
CYP3A4 P08684 1/20 0.36
THRB P10828 1/20 0.36
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
KDM4E B2RXH2 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5037971 0.84 TRPA1 (0.40) ALDH1A1SMN1; SMN2L3MBTL1TRPA1FFAR1
SCHEMBL7091860 0.83 MAPT (0.42) ALDH1A1MAPTKMT2AGAASMN1; SMN2
SCHEMBL7096863 0.81 ESR1 (0.35) ALDH1A1MAPK1CYP3A4RAB9ALMNA
SCHEMBL26507116 0.78 NR3C2 (0.40) KMT2ASMN1; SMN2MEN1KDM4EPOLB
SCHEMBL30108108 0.78 NR3C2 (0.40) KMT2ASMN1; SMN2MEN1KDM4EPOLB
SCHEMBL7095297 0.78 MEN1 (0.48) ALDH1A1MAPTKMT2AGAASMN1; SMN2
SCHEMBL27600931 0.78 CA4 (0.46) ALDH1A1KMT2ACA12CA1CA2
SCHEMBL7095778 0.77 LMNA (0.42) ALDH1A1MAPTKMT2AGAASMN1; SMN2
SCHEMBL5236553 0.77 CA4 (0.40) ALDH1A1MAPTKMT2ASMN1; SMN2MAPK1
SCHEMBL7148596 0.76 CA12 (0.39) CA12CA1CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250353874-A1 GLUCOCORTICOID RECEPTOR AGONISTS LILLY CO ELI (US) 2025-11-20 US disclosed
US-12404298-B2 Glucocorticoid receptor agonists ELI LILLY AND COMPANY (US) 2025-09-02 US disclosed
EP-4314004-B1 CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS LILLY CO ELI (US) 2025-01-22 EP disclosed
US-12162905-B2 Carboxy substituted glucocorticoid receptor agonists ELI LILLY AND COMPANY (US) 2024-12-10 US disclosed
EP-4314005-A1 GLUCOCORTICOID RECEPTOR AGONISTS Eli Lilly and Company (US) 2024-02-07 EP disclosed
EP-4314004-A1 CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS Eli Lilly and Company (US) 2024-02-07 EP disclosed
US-20240018182-A1 GLUCOCORTICOID RECEPTOR AGONISTS ELI LILLY AND COMPANY 2024-01-18 US disclosed
US-20240018182-A1 GLUCOCORTICOID RECEPTOR AGONISTS ELI LILLY AND COMPANY 2024-01-18 US disclosed
US-20240018182-A1 GLUCOCORTICOID RECEPTOR AGONISTS ELI LILLY AND COMPANY 2024-01-18 US disclosed
CN-117043172-A Glucocorticoid receptor agonists 伊莱利利公司 2023-11-10 CN disclosed
US-11787834-B2 Glucocorticoid receptor agonists ELI LILLY AND COMPANY (US) 2023-10-17 US disclosed
CN-116888137-A Carboxy substituted glucocorticoid receptor agonists 伊莱利利公司 2023-10-13 CN disclosed
US-20230227493-A1 CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS ELI LILLY AND COMPANY 2023-07-20 US disclosed
US-20230227493-A1 CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS ELI LILLY AND COMPANY 2023-07-20 US disclosed
US-11618767-B2 Carboxy substituted glucocorticoid receptor agonists ELI LILLY AND COMPANY (US) 2023-04-04 US disclosed
US-20220324904-A1 GLUCOCORTICOID RECEPTOR AGONISTS ELI LILLY AND COMPANY 2022-10-13 US disclosed
WO-2022204099-A1 CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2022-09-29 WO disclosed
WO-2022204108-A1 GLUCOCORTICOID RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2022-09-29 WO disclosed
US-20220306681-A1 CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS ELI LILLY AND COMPANY 2022-09-29 US disclosed
US-20220306681-A1 CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS ELI LILLY AND COMPANY 2022-09-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230227493-A1 CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS NR3C1, MC2R, NR3C2 ALDH1A1 2971/4885KIF11 4482/4885MAPT 4721/4885
US-20220306681-A1 CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS NR3C1, MC2R, NR3C2 ALDH1A1 2971/4885KIF11 4482/4885MAPT 4721/4885
US-12404298-B2 Glucocorticoid receptor agonists NR3C1, NR3C2, MC2R ALDH1A1 3227/4885KIF11 4147/4885MAPT 3892/4885
US-20240018182-A1 GLUCOCORTICOID RECEPTOR AGONISTS NR3C1, NR3C2, MC2R ALDH1A1 3227/4885KIF11 4147/4885MAPT 3892/4885
US-20250353874-A1 GLUCOCORTICOID RECEPTOR AGONISTS NR3C1, NR3C2, MC2R ALDH1A1 3227/4885KIF11 4147/4885MAPT 3892/4885
US-11787834-B2 Glucocorticoid receptor agonists NR3C1, NR3C2, MC2R ALDH1A1 3227/4885KIF11 4147/4885MAPT 3892/4885
US-20220324904-A1 GLUCOCORTICOID RECEPTOR AGONISTS NR3C1, NR3C2, MC2R ALDH1A1 3227/4885KIF11 4147/4885MAPT 3892/4885
US-11618767-B2 Carboxy substituted glucocorticoid receptor agonists NR3C1, MC2R, NR3C2 ALDH1A1 2971/4885KIF11 4482/4885MAPT 4721/4885
US-12162905-B2 Carboxy substituted glucocorticoid receptor agonists NR3C1, MC2R, NR3C2 ALDH1A1 2971/4885KIF11 4482/4885MAPT 4721/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.