Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13570088 | 0.82 | ALDH1A1 (0.43) | ALDH1A1HSD11B1CYP1A2SIGMAR1CARM1 | |
| SCHEMBL24378839 | 0.81 | HSD11B1 (0.42) | ALDH1A1HSD11B1CYP1A2CYP2D6SIGMAR1 | |
| SCHEMBL12449627 | 0.79 | ALDH1A1 (0.48) | ALDH1A1CYP1A2CYP2D6SIGMAR1CARM1 | |
| SCHEMBL12720 | 0.79 | ALDH1A1 (0.48) | ALDH1A1CYP1A2CYP2D6SIGMAR1CARM1 | |
| SCHEMBL25001376 | 0.78 | HSD11B1 (0.38) | ALDH1A1HSD11B1CYP1A2CYP2D6ALOX15 | |
| SCHEMBL12607 | 0.78 | ALDH1A1 (0.53) | ALDH1A1CYP1A2CYP2D6SIGMAR1CARM1 | |
| SCHEMBL21227408 | 0.77 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2D6SIGMAR1CARM1 | |
| SCHEMBL24327679 | 0.74 | ALDH1A1 (0.37) | ALDH1A1HSD11B1SIGMAR1KDM1AGBA1 | |
| SCHEMBL18327901 | 0.74 | CYP2D6 (0.47) | ALDH1A1HSD11B1CYP1A2CYP2D6ALOX15 | |
| SCHEMBL25907682 | 0.73 | HSD11B1 (0.37) | ALDH1A1HSD11B1CYP2D6KDM4EKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4083038-A1 | PYRIDAZINYL THIAZOLECARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2022-11-02 | — | — | EP | disclosed |