Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 6/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 6/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2467985 | 0.85 | HDAC4 (0.43) | HDAC4HDAC8ERN1TYRCYP1A1 | |
| SCHEMBL2290188 | 0.81 | ALDH1A1 (0.59) | HDAC4HDAC8ERN1TYRCYP1A1 | |
| SCHEMBL13557887 | 0.78 | TYR (0.47) | HDAC4HDAC8TYRALDH1A1MAPT | |
| SCHEMBL84033 | 0.76 | PPARG (0.53) | HDAC4HDAC8CYP1A2ALDH1A1MAPT | |
| SCHEMBL3785302 | 0.75 | CYP1A2 (0.70) | CYP1A1CYP1A2CYP1B1NFE2L2ALDH1A1 | |
| SCHEMBL21167752 | 0.75 | TYR (0.44) | TYRALDH1A1MAPTL3MBTL1POLB | |
| SCHEMBL24240700 | 0.75 | LMNA (0.47) | TYRALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL4199940 | 0.74 | HDAC4 (0.43) | HDAC4HDAC8ERN1TYRCYP1A1 | |
| SCHEMBL7448262 | 0.74 | TYR (0.53) | HDAC4HDAC8ERN1TYRNFE2L2 | |
| SCHEMBL12870076 | 0.74 | KDM4E (0.57) | NFE2L2ALDH1A1MAPTMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235575-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | PETRA PHARMA CORPORATION (US) | 2022-11-10 | — | — | WO | disclosed |