Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | GABBR2 | O75899 | 8/20 | 0.37 |
| ▸ | GABBR1 | Q9UBS5 | 8/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27145348 | 0.89 | HTR2A (0.44) | HTR2AGABBR2GABBR1LMNACYP2C9 | |
| SCHEMBL15786506 | 0.89 | HTR2A (0.44) | HTR2AGABBR2GABBR1LMNACYP2C9 | |
| SCHEMBL11079558 | 0.83 | HTR2A (0.58) | HTR2AGABBR2GABBR1LMNACYP2C9 | |
| Hydrochloric Acid SCHEMBL1866896 | 0.81 | HTR2A (0.56) | HTR2AGABBR2GABBR1LMNACYP2C9 | |
| SCHEMBL13210867 | 0.80 | HDAC8 (0.42) | HTR2ACYP1A2ALOX5 | |
| SCHEMBL5327386 | 0.80 | GABBR2 (0.56) | GABBR2GABBR1LMNACYP2C9CYP1A2 | |
| SCHEMBL5321547 | 0.80 | GABBR2 (0.56) | GABBR2GABBR1LMNACYP2C9CYP1A2 | |
| SCHEMBL7669749 | 0.80 | GABBR2 (0.58) | GABBR2GABBR1LMNACYP2C9CYP1A2 | |
| SCHEMBL2628024 | 0.79 | GABBR2 (0.57) | HTR2AGABBR2GABBR1LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL8987270 | 0.78 | GABBR2 (0.55) | HTR2AGABBR2GABBR1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |