Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 3/20 | 0.57 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8987270 | 0.98 | GABBR2 (0.55) | GABBR2GABBR1TAAR1HTR2AHRH1 | |
| SCHEMBL27970111 | 0.88 | GABBR2 (0.53) | GABBR2GABBR1TAAR1HTR2AHRH1 | |
| SCHEMBL1308070 | 0.86 | TRPA1 (0.52) | GABBR2GABBR1TAAR1HTR2AHRH1 | |
| SCHEMBL4789777 | 0.82 | GABBR2 (0.61) | GABBR2GABBR1TAAR1HTR2AHRH1 | |
| SCHEMBL9787802 | 0.82 | GABBR2 (0.61) | GABBR2GABBR1TAAR1HTR2AHRH1 | |
| SCHEMBL1986953 | 0.82 | GABBR2 (0.61) | GABBR2GABBR1TAAR1HTR2AHRH1 | |
| SCHEMBL8274952 | 0.82 | TRPA1 (0.48) | GABBR2GABBR1TAAR1HTR2AHRH1 | |
| SCHEMBL1546696 | 0.82 | TRPA1 (0.48) | GABBR2GABBR1TAAR1HTR2AHRH1 | |
| SCHEMBL9137323 | 0.82 | HRH1 (0.62) | GABBR2GABBR1TAAR1HTR2AHRH1 | |
| SCHEMBL1507699 | 0.82 | TRPA1 (0.48) | GABBR2GABBR1TAAR1HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0725780-A1 | STABILIZATION OF CYCLIC ACETALS | HOECHST CELANESE CORPORATION (US) | 1996-08-14 | — | — | EP | claimed |
| EP-0725780-A4 | STABILIZATION OF CYCLIC ACETALS | HOECHST CELANESE CORP (US) | 1996-06-12 | — | — | EP | claimed |
| WO-1995011892-A1 | STABILIZATION OF CYCLIC ACETALS | HOECHST CELANESE CORPORATION (US) | 1995-05-04 | — | — | WO | claimed |
| EP-3541373-B1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME LLC (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3541373-B1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME LLC (US) | 2023-11-01 | — | — | EP | disclosed |
| US-20210380548-A1 | Fused [1,2,4]Thiadiazine Derivatives Which Act as KAT Inhibitors of the MYST Family | CTXT PTY LIMITED (AU) | 2021-12-09 | — | — | US | disclosed |
| US-20210380548-A1 | Fused [1,2,4]Thiadiazine Derivatives Which Act as KAT Inhibitors of the MYST Family | CTXT PTY LIMITED (AU) | 2021-12-09 | — | — | US | disclosed |
| US-10968210-B2 | Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels | MERCK SHARP & DOHME CORP. (US) | 2021-04-06 | — | — | US | disclosed |
| US-10968210-B2 | Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels | MERCK SHARP & DOHME CORP. (US) | 2021-04-06 | — | — | US | disclosed |
| EP-3676266-A1 | FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY | Ctxt Pty Ltd (AU) | 2020-07-08 | — | — | EP | disclosed |
| US-20200131167-A1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME CORP. (US) | 2020-04-30 | — | — | US | disclosed |
| US-7915410-B2 | Acyclic IKur inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-03-29 | — | — | US | disclosed |
| US-7915410-B2 | Acyclic IKur inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-03-29 | — | — | US | disclosed |
| US-20070270487-A1 | Novel process and intermediates 085 | ASTRAZENECA AB (SE) | 2007-11-22 | — | — | US | disclosed |
| US-20070082909-A1 | Acyclic Ikur inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-04-12 | — | — | US | disclosed |
| US-20070082909-A1 | Acyclic Ikur inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-04-12 | — | — | US | disclosed |
| WO-2007030582-A2 | ACYCLIC IKUR INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-03-15 | — | — | WO | disclosed |
| EP-0725780-A1 | STABILIZATION OF CYCLIC ACETALS | HOECHST CELANESE CORPORATION (US) | 1996-08-14 | — | — | EP | disclosed |
| EP-0725780-A4 | STABILIZATION OF CYCLIC ACETALS | HOECHST CELANESE CORP (US) | 1996-06-12 | — | — | EP | disclosed |
| WO-1995011892-A1 | STABILIZATION OF CYCLIC ACETALS | HOECHST CELANESE CORPORATION (US) | 1995-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10968210-B2 | Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels | TRPV1, SCN1A, SCN7A | GABBR2 2167/4885GABBR1 1814/4885TAAR1 160/4885 |
| US-20210380548-A1 | Fused [1,2,4]Thiadiazine Derivatives Which Act as KAT Inhibitors of the MYST Family | KAT5, KAT6A, KAT2A | GABBR2 3937/4885GABBR1 3990/4885TAAR1 1982/4885 |
| US-20070270487-A1 | Novel process and intermediates 085 | CYP3A5, AGPAT5, CYP4F8 | GABBR2 1606/4885GABBR1 1299/4885TAAR1 2953/4885 |
| US-20070082909-A1 | Acyclic Ikur inhibitors | KCNH2, KCNJ2, KCNH3 | GABBR2 1126/4885GABBR1 1118/4885TAAR1 504/4885 |
| US-20200131167-A1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | TRPV1, SCN1A, SCN7A | GABBR2 2167/4885GABBR1 1814/4885TAAR1 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.