SCHEMBL246944

SCHEMBL246944

Clc1ccccc1Pc1ccccc1Cl

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.53
LMNA P02545 2/20 0.53
ALDH1A1 P00352 3/20 0.41
CYP2A6 P11509 4/20 0.38
CYP1A2 P05177 3/20 0.38
CES2 O00748 1/20 0.36
CES1 P23141 1/20 0.36
PNMT P11086 1/20 0.36
IDO1 P14902 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.34
TAAR1 Q96RJ0 1/20 0.33
ADRB2 P07550 1/20 0.33
ADRB1 P08588 1/20 0.33
ADRA2A P08913 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
POLB P06746 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2155084 0.97 TSHR (0.50) TSHRLMNAALDH1A1CYP2A6CYP1A2
SCHEMBL8745400 0.84 TSHR (0.43) TSHRLMNAALDH1A1CYP2A6CYP1A2
Hydrochloric Acid SCHEMBL2154232 0.82 TSHR (0.41) TSHRLMNAALDH1A1CYP2A6CYP1A2
SCHEMBL18544199 0.82 TSHR (0.36) TSHRLMNAALDH1A1PNMTIDO1
SCHEMBL8013185 0.77 TSHR (0.36) TSHRLMNAALDH1A1ADRB2ADRB1
SCHEMBL4899299 0.75 TSHR (0.45) TSHRLMNAALDH1A1CYP2A6CYP1A2
1,2-Dichlorobenzene SCHEMBL5190 0.71
1,2-Dichlorobenzene SCHEMBL10593125 0.71
1,2-Dichlorobenzene SCHEMBL1155123 0.71 TSHR (1.00) TSHRLMNAALDH1A1CYP2A6CYP1A2
1,2-Dichlorobenzene SCHEMBL29350623 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10731040-B2 Crosslinked phenolic compound, method of forming, and polymer composition containing the same THE UNIVERSITY OF MASSACHUSETTS (US) 2020-08-04 US claimed
US-20180016445-A1 CROSSLINKED PHENOLIC COMPOUND, METHOD OF FORMING, AND POLYMER COMPOSITION CONTAINING THE SAME THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY 2018-01-18 US claimed
EP-0205124-B1 PROCESS FOR THE PREPARATION OF POLYARYLENE POLYETHERS CONTAINING PHOSPHOROUS RÖHM GMBH (DE) 1990-01-31 EP claimed
US-20250368598-A1 CATALYTIC CARBOXYCARBONYLATION OF ALKENES TO FORM ANHYDRIDES BHATTACHARYA SHRABANTI (US) 2025-12-04 US disclosed
WO-2025235763-A1 FLUORESCENT PROBES AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-11-13 WO disclosed
US-20250154109-A1 SODIUM CHANNEL BLOCKING COMPOUNDS, DERIVATIVES THEREOF, AND METHODS OF THEIR USE LATIGO BIOTHERAPEUTICS, INC 2025-05-15 US disclosed
US-12291489-B2 Synthesis of nanocomposites and their use in enhancing plant nutrition WASHINGTON UNIVERSITY (US) 2025-05-06 US disclosed
EP-4543841-A2 CATALYTIC CARBOXYCARBONYLATION OF ALKENES TO FORM ANHYDRIDES The University of North Carolina at Chapel Hill (US) 2025-04-30 EP disclosed
WO-2023250180-A2 CATALYTIC CARBOXYCARBONYLATION OF ALKENES TO FORM ANHYDRIDES THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2023-12-28 WO disclosed
EP-2902456-B1 INK COMPOSITION, INK JET RECORDING METHOD, PRINTED MATERIAL, BISACYL PHOSPHINE OXIDE COMPOUND, AND MONOACYL PHOSPHINE OXIDE COMPOUND FUJIFILM CORP (JP) 2020-10-21 EP disclosed
US-10731040-B2 Crosslinked phenolic compound, method of forming, and polymer composition containing the same THE UNIVERSITY OF MASSACHUSETTS (US) 2020-08-04 US disclosed
WO-2000032612-A1 PROCESS FOR PREPARING ACYLPHOSPHINES AND DERIVATIVES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2000-06-08 WO disclosed
US-4716255-A CATALYTIC CHLORINATION OF 1-CHLORO-2-METHYLPROPENE WITH SULFURYL CHLORIDE HUELS AKTIENGESELLSCHAFT (DE) 1987-12-29 US disclosed
US-4714792-A CATALYTIC CHLORINATION OF ALLYL CHLORIDE WITH SULFURYL CHLORIDE HUELS AKTIENGESELLSCHAFT (DE) 1987-12-22 US disclosed
US-4587367-A CHLORINATION HUELS AKTIENGESELLSCHAFT (DE) 1986-05-06 US disclosed
US-4471048-A PHOSPHO AND AMINO PHOSPHOBENZENE COMPOUNDS TO ACDELERATE REDUCTION OF SILVER HALIDE; RECORDING CIBA GEIGY AG (CH) 1984-09-11 US disclosed
EP-0041662-B1 RESIN ENCAPSULATION TYPE SEMICONDUCTOR DEVICE KABUSHIKI KAISHA TOSHIBA (JP) 1984-04-11 EP disclosed
US-4436811-A DEVELOPMENT ACCELERATORS CIBA-GEIGY AG (CH) 1984-03-13 US disclosed
EP-0070254-A1 Photographic material containing a development accelerator CIBA-GEIGY AG (CH) 1983-01-19 EP disclosed
EP-0041662-A1 Resin encapsulation type semiconductor device KABUSHIKI KAISHA TOSHIBA (JP) 1981-12-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250154109-A1 SODIUM CHANNEL BLOCKING COMPOUNDS, DERIVATIVES THEREOF, AND METHODS OF THEIR USE SCN8A, TRPV1, SCNN1A TSHR 3667/4885LMNA 2140/4885ALDH1A1 2842/4885
US-20250368598-A1 CATALYTIC CARBOXYCARBONYLATION OF ALKENES TO FORM ANHYDRIDES CA4, CA12, CA14 TSHR 4615/4885LMNA 3247/4885ALDH1A1 688/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.