Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8740901 | 0.74 | AKT2 (0.45) | AKT2CHEK1PDGFRAMAPK8CDK5 | |
| SCHEMBL9459084 | 0.72 | HTT (0.50) | AKT2CHEK1PDGFRAMAPK8CDK5 | |
| SCHEMBL28312780 | 0.69 | FABP4 (0.42) | AKT2HTTKMT2ALMNAMAPT | |
| SCHEMBL10462527 | 0.67 | CSNK2A1 (0.47) | PDGFRAMAPK8CDK5CLK4HTT | |
| SCHEMBL12670780 | 0.67 | CHUK (0.47) | AKT2CHEK1CDK5HTTGAA | |
| SCHEMBL24697367 | 0.67 | KDM4E (0.36) | GAAMAPTALDH1A1HSD17B10RAB9A | |
| SCHEMBL18152025 | 0.62 | PTGS2 (0.45) | CLK4KMT2AALDH1A1HSD17B10MEN1 | |
| SCHEMBL27691326 | 0.62 | HDAC4 (0.42) | HTTALOX15KMT2ALMNAMAPT | |
| SCHEMBL12360715 | 0.61 | HTT (0.51) | AKT2CHEK1MAPK8CDK5CLK4 | |
| SCHEMBL27655636 | 0.60 | MAPT (0.40) | HTTGAAALOX15KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022254027-A1 | 3-PYRROLYLSULFONAMIDE COMPOUNDS AS GPR17 ANTAGONISTS | REWIND THERAPEUTICS NV (BE) | 2022-12-08 | — | — | WO | disclosed |