SCHEMBL2469724

SCHEMBL2469724

Nc1cc(-c2ccc(Cl)cc2C(F)(F)F)nc(OC(=O)O)c1Cl

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ACHE P22303 3/20 0.40
CFTR P13569 1/20 0.38
KDM4C Q9H3R0 1/20 0.37
MRGPRX4 Q96LA9 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
RAB9A P51151 1/20 0.36
SCN9A Q15858 2/20 0.35
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 1/20 0.35
HSD17B10 Q99714 1/20 0.35
JAK2 O60674 1/20 0.35
GRM5 P41594 1/20 0.35
PTGDR2 Q9Y5Y4 1/20 0.34
TP53 P04637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9938973 0.85 CYP3A4 (0.40) ALDH1A1HSD17B10
SCHEMBL2468072 0.84 KMO (0.47) SCN9AJAK2
SCHEMBL2468346 0.84 HSP90AA1 (0.47) RAB9AKDM4E
SCHEMBL2470388 0.82 GRM2 (0.41) KDM4CMRGPRX4CYP1A2CYP2C19
SCHEMBL2469723 0.82 CFTR (0.41) ACHECFTRKDM4CMRGPRX4CYP1A2
SCHEMBL2468292 0.82 AGPAT2 (0.41) ALDH1A1JAK2TP53
SCHEMBL2464042 0.81 ALOX5AP (0.38) ACHECFTRSCN9A
SCHEMBL2466891 0.81 NPSR1 (0.42) CFTRMRGPRX4CYP1A2CYP2C19KDM4E
SCHEMBL2469714 0.80 HSP90AA1 (0.52) KDM4EALDH1A1
SCHEMBL2469711 0.80 CYP3A4 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2369929-A2 HERBICIDE-SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP disclosed
WO-2010060581-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO disclosed
EP-2191719-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-06-02 EP disclosed