SCHEMBL2469714

SCHEMBL2469714

COc1cc(Cl)ccc1-c1cc(N)c(Cl)c(OC(=O)O)n1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.52
HSP90AB1 P08238 2/20 0.52
MAPK1 P28482 2/20 0.41
PIK3CA P42336 1/20 0.40
MAPK8 P45983 1/20 0.40
MAPK9 P45984 1/20 0.40
MAPK10 P53779 1/20 0.40
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 2/20 0.39
CTSA P10619 2/20 0.38
AGPAT2 O15120 5/20 0.38
LMNA P02545 1/20 0.37
MEN1 O00255 1/20 0.37
POLB P06746 1/20 0.37
KMT2A Q03164 1/20 0.37
CNR1 P21554 1/20 0.36
HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2468802 0.87 HSP90AA1 (0.52) HSP90AA1HSP90AB1KDM4ELMNAKMT2A
SCHEMBL9938973 0.86 CYP3A4 (0.40) HSP90AA1HSP90AB1MAPK1ALDH1A1HPGD
SCHEMBL2470388 0.85 GRM2 (0.41) HSP90AA1HSP90AB1AGPAT2
SCHEMBL2468346 0.85 HSP90AA1 (0.47) HSP90AA1HSP90AB1KDM4ELMNAMEN1
SCHEMBL2468072 0.83 KMO (0.47) MAPK1MAPK8MAPK9
SCHEMBL2469712 0.83 HSP90AA1 (0.54) HSP90AA1HSP90AB1MAPK1PIK3CAMAPK8
SCHEMBL2468292 0.83 AGPAT2 (0.41) HSP90AA1HSP90AB1ALDH1A1AGPAT2
SCHEMBL17797261 0.82 PDCD1LG2 (0.40) HSP90AA1HSP90AB1
SCHEMBL2466531 0.82 CYP2D6 (0.47) HSP90AA1HSP90AB1KDM4EALDH1A1LMNA
SCHEMBL2468243 0.82 ALDH1A1 (0.38) HSP90AA1HSP90AB1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2369929-A2 HERBICIDE-SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP disclosed
WO-2010060581-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO disclosed
EP-2191719-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-06-02 EP disclosed