Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 5/20 | 0.45 |
| ▸ | ABCC8 | Q09428 | 5/20 | 0.45 |
| ▸ | KCNJ11 | Q14654 | 5/20 | 0.45 |
| ▸ | KCNJ8 | Q15842 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10252235 | 0.86 | L3MBTL1 (0.42) | ABCC9ABCC8KCNJ11KCNJ8LMNA | |
| SCHEMBL10248574 | 0.79 | TSHR (0.46) | ALDH1A1LMNAGAAKDM4EHDAC1 | |
| SCHEMBL2476256 | 0.76 | EPHX2 (0.40) | ABCC9ABCC8KCNJ11KCNJ8ALDH1A1 | |
| SCHEMBL30937653 | 0.74 | L3MBTL1 (0.44) | ALDH1A1ALOX12LMNAGAAKDM4E | |
| SCHEMBL14254883 | 0.73 | HTT (0.55) | ALDH1A1ALOX12LMNAGAAKDM4E | |
| SCHEMBL14254877 | 0.73 | HTT (0.60) | ALDH1A1LMNAGAARAB9AMAPT | |
| SCHEMBL29952711 | 0.72 | L3MBTL1 (0.42) | ALDH1A1ALOX12LMNAKDM4EL3MBTL1 | |
| SCHEMBL6644009 | 0.71 | LTA4H (0.46) | ABCC9ABCC8KCNJ11KCNJ8ALDH1A1 | |
| SCHEMBL27508225 | 0.71 | L3MBTL1 (0.44) | ABCC9ABCC8KCNJ11KCNJ8ALDH1A1 | |
| SCHEMBL30937617 | 0.71 | ALDH1A1 (0.41) | ALDH1A1ALOX12LMNAGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858520-B1 | QUINAZOLINONE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK SHARP & DOHME (US) | 2011-10-05 | — | — | EP | disclosed |
| EP-1858520-B1 | QUINAZOLINONE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK SHARP & DOHME (US) | 2011-10-05 | — | — | EP | disclosed |
| US-20100261741-A1 | Quinazolinone T-Type Calcium Channel Antagonists | MERCK (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100261741-A1 | Quinazolinone T-Type Calcium Channel Antagonists | MERCK (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100261741-A1 | Quinazolinone T-Type Calcium Channel Antagonists | MERCK (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100210671-A1 | Quinazolinone T-Type Calcium Channel Antagonists | MERCK SHARP & DOHME CORP. | 2010-08-19 | — | — | US | disclosed |
| US-20100210671-A1 | Quinazolinone T-Type Calcium Channel Antagonists | MERCK SHARP & DOHME CORP. | 2010-08-19 | — | — | US | disclosed |
| US-20100210671-A1 | Quinazolinone T-Type Calcium Channel Antagonists | MERCK SHARP & DOHME CORP. | 2010-08-19 | — | — | US | disclosed |
| US-7745452-B2 | Quinazolinone T-type calcium channel antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-06-29 | — | — | US | disclosed |
| US-7745452-B2 | Quinazolinone T-type calcium channel antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-06-29 | — | — | US | disclosed |
| US-7745452-B2 | Quinazolinone T-type calcium channel antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-06-29 | — | — | US | disclosed |
| EP-2175725-A1 | QUINAZOLINONE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009009015-A1 | QUINAZOLINONE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2009-01-15 | — | — | WO | disclosed |
| US-20080167329-A1 | Quinazolinone T-Type Calcium Channel Antagonists | MERCK SHARP & DOHME LLC | 2008-07-10 | — | — | US | disclosed |
| US-20080167329-A1 | Quinazolinone T-Type Calcium Channel Antagonists | MERCK SHARP & DOHME LLC | 2008-07-10 | — | — | US | disclosed |
| US-20080167329-A1 | Quinazolinone T-Type Calcium Channel Antagonists | MERCK SHARP & DOHME LLC | 2008-07-10 | — | — | US | disclosed |
| EP-1858520-A2 | QUINAZOLINONE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck & Co., Inc. (US) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006098969-A2 | QUINAZOLINONE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2006-09-21 | — | — | WO | disclosed |
| WO-2006098969-A2 | QUINAZOLINONE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2006-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261741-A1 | Quinazolinone T-Type Calcium Channel Antagonists | CACNA1I, CACNA1G, CACNA1H | ABCC9 356/4885ABCC8 850/4885KCNJ11 54/4885 |
| US-20080167329-A1 | Quinazolinone T-Type Calcium Channel Antagonists | CACNA1I, CACNA1G, CACNA1H | ABCC9 356/4885ABCC8 850/4885KCNJ11 54/4885 |
| US-20100210671-A1 | Quinazolinone T-Type Calcium Channel Antagonists | CACNA1I, CACNA1G, CACNA1H | ABCC9 356/4885ABCC8 850/4885KCNJ11 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.