Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BPTF | Q12830 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24699003 | 0.88 | PRMT6 (0.39) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL24697814 | 0.87 | HRH3 (0.44) | HRH2HRH3ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL24698524 | 0.87 | HRH2 (0.39) | HRH2HRH3KDM4EALDH1A1HPGD | |
| SCHEMBL24698120 | 0.86 | HRH2 (0.39) | HRH2HRH3KDM4EALDH1A1HPGD | |
| SCHEMBL24697738 | 0.85 | HRH2 (0.38) | HRH2HRH3ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL24699432 | 0.85 | HRH2 (0.38) | HRH2HRH3KDM4EALDH1A1HPGD | |
| SCHEMBL24697825 | 0.84 | NCF1 (0.41) | HRH2HRH3KDM4EALDH1A1HPGD | |
| SCHEMBL24698157 | 0.84 | HRH3 (0.43) | HRH2HRH3KDM4EALDH1A1HPGD | |
| SCHEMBL24697795 | 0.82 | ALDH1A1 (0.40) | HRH2HRH3KDM4EALDH1A1HPGD | |
| SCHEMBL24698171 | 0.82 | ALDH1A1 (0.54) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |