Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 5/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24698948 | 0.86 | NISCH (0.38) | NISCHKDM4EALDH1A1L3MBTL1MTOR | |
| SCHEMBL24699403 | 0.84 | NISCH (0.36) | NISCHKDM4EALDH1A1MTORADK | |
| SCHEMBL24698946 | 0.80 | MTOR (0.42) | NISCHKDM4EALDH1A1MTORADK | |
| SCHEMBL24698426 | 0.77 | KARS1 (0.40) | KDM4EALDH1A1MTORHRH3HCRTR1 | |
| SCHEMBL24698113 | 0.77 | HRH2 (0.36) | KDM4EALDH1A1MAPTTP53L3MBTL1 | |
| SCHEMBL24699432 | 0.77 | HRH2 (0.38) | KDM4EALDH1A1MAPTTP53L3MBTL1 | |
| SCHEMBL24698868 | 0.76 | PDE2A (0.38) | KDM4EALDH1A1HRH3HCRTR1HCRTR2 | |
| SCHEMBL24698181 | 0.76 | GBA1 (0.38) | KDM4EALDH1A1MAPTTP53L3MBTL1 | |
| SCHEMBL24699006 | 0.75 | KDM4E (0.39) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL24698195 | 0.75 | PRKACA (0.38) | KDM4EMAPTTP53L3MBTL1TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |