Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 3/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | EEF2K | O00418 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24698162 | 0.89 | EEF2K (0.38) | GBA1MKNK1MKNK2EEF2KPIK3CA | |
| SCHEMBL24699476 | 0.87 | GBA1 (0.39) | GBA1CDC7CDK9PIK3CAPIK3CD | |
| SCHEMBL24699356 | 0.86 | GBA1 (0.47) | GBA1CDC7CDK9KDM4EALDH1A1 | |
| SCHEMBL30015877 | 0.85 | PDK1 (0.40) | MKNK1MKNK2EEF2KPIK3CAPIK3CD | |
| SCHEMBL24699461 | 0.85 | PDK1 (0.40) | MKNK1MKNK2EEF2KPIK3CAPIK3CD | |
| SCHEMBL24698767 | 0.84 | GBA1 (0.38) | GBA1CDC7CDK9KDM4EALDH1A1 | |
| SCHEMBL24699485 | 0.84 | KDM4E (0.42) | GBA1MKNK1MKNK2KDM4EALDH1A1 | |
| SCHEMBL24698163 | 0.82 | PDK2 (0.36) | MKNK1MKNK2EEF2KPIK3CAPIK3CD | |
| SCHEMBL30016283 | 0.82 | PDK2 (0.36) | MKNK1MKNK2EEF2KPIK3CAPIK3CD | |
| SCHEMBL24699054 | 0.82 | GBA1 (0.38) | GBA1CDC7CDK9PIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |