Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 2/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | MTOR | P42345 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | HCK | P08631 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24699459 | 0.89 | GBA1 (0.39) | EEF2KPDK2PDK1PDK3PDK4 | |
| SCHEMBL24698780 | 0.88 | PDE10A (0.43) | PDK2PDK1PDK3PDK4SIRT1 | |
| SCHEMBL30016283 | 0.85 | PDK2 (0.36) | EEF2KPDK2PDK1PDK3PDK4 | |
| SCHEMBL24698163 | 0.85 | PDK2 (0.36) | EEF2KPDK2PDK1PDK3PDK4 | |
| SCHEMBL24698868 | 0.83 | PDE2A (0.38) | EEF2KPDK2PDK1PDK3PDK4 | |
| SCHEMBL30015877 | 0.82 | PDK1 (0.40) | EEF2KPDK2PDK1PDK3PDK4 | |
| SCHEMBL24699461 | 0.82 | PDK1 (0.40) | EEF2KPDK2PDK1PDK3PDK4 | |
| SCHEMBL24698430 | 0.81 | PIK3CA (0.46) | KDM4EPIK3CATP53ALDH1A1NPSR1 | |
| SCHEMBL24698426 | 0.77 | KARS1 (0.40) | EEF2KPDK2PDK1PDK3PDK4 | |
| SCHEMBL24698917 | 0.76 | PDE10A (0.39) | EEF2KMKNK1MKNK2PIK3CAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |