Sugi Predict

Sugi Predict / Compounds / SCHEMBL2469996

SCHEMBL2469996

SCHEMBL2469996

COC(=O)c1cc(O)c2ccc(Br)cc2c1C

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR4A2 P43354 2/20 0.51
▸ L3MBTL1 Q9Y468 1/20 0.48
▸ CHEK1 O14757 1/20 0.46
▸ TSHR P16473 3/20 0.43
▸ HTT P42858 1/20 0.43
▸ CA12 O43570 2/20 0.42
▸ CA1 P00915 2/20 0.42
▸ CA2 P00918 2/20 0.42
▸ CA7 P43166 2/20 0.42
▸ CA9 Q16790 2/20 0.42
▸ CA14 Q9ULX7 2/20 0.42
▸ PDK2 Q15119 1/20 0.42
▸ PDK4 Q16654 1/20 0.42
▸ SMN1; SMN2 Q16637 3/20 0.42
▸ LMNA P02545 1/20 0.41
▸ GAA P10253 2/20 0.41
▸ ALDH1A1 P00352 2/20 0.41
▸ ESR2 Q92731 1/20 0.40
▸ MAPK14 Q16539 1/20 0.40
▸ SLC6A3 Q01959 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15214803 0.86 NR4A2 (0.52) NR4A2L3MBTL1CHEK1TSHRHTT
SCHEMBL1531831 0.85 TSHR (0.52) NR4A2L3MBTL1CHEK1TSHRHTT
SCHEMBL2469717 0.84 TSHR (0.47) NR4A2TSHRSMN1; SMN2LMNAGAA
SCHEMBL2466414 0.83 RXFP1 (0.46) L3MBTL1HTTALDH1A1ESR2MAPT
SCHEMBL2470133 0.81 LMNA (0.55) NR4A2TSHRHTTCA12CA1
SCHEMBL2472046 0.78 PTPN11 (0.40) TSHRCA12CA1CA2CA7
SCHEMBL9331693 0.77 NR4A2 (0.47) NR4A2L3MBTL1CHEK1TSHRHTT
SCHEMBL6172886 0.76 NR4A2 (0.51) NR4A2L3MBTL1HTTCA12CA1
SCHEMBL27165418 0.75 SLC6A3 (0.44) NR4A2L3MBTL1CHEK1CA12CA1
SCHEMBL1378325 0.75 CA12 (0.67) NR4A2L3MBTL1TSHRCA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105199708-B Photochromic compounds 光学转变公司 2020-10-27 — — CN disclosed
EP-2370420-B9 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2019-11-13 — — EP disclosed
EP-2370420-B1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2019-05-22 — — EP disclosed
US-20180291009-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2018-10-11 — — US disclosed
US-20180291008-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2018-10-11 — — US disclosed
US-20180291007-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2018-10-11 — — US disclosed
US-10005763-B2 Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2018-06-26 — — US disclosed
US-10000472-B2 Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2018-06-19 — — US disclosed
US-20160333262-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2016-11-17 — — US disclosed
US-20160332995-A1 Photochromic Comounds TRANSITIONS OPTICAL, INC. 2016-11-17 — — US disclosed
CN-105199708-A Photochromic compounds TRANSITIONS OPTICAL INC 2015-12-30 — — CN disclosed
CN-102272114-B Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2015-09-02 — — CN disclosed
US-20140154514-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2014-06-05 — — US disclosed
US-8705160-B2 Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2014-04-22 — — US disclosed
US-20120200907-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2012-08-09 — — US disclosed
US-8211338-B2 Photochromic compounds TRANSITIONS OPTICAL, INC (US) 2012-07-03 — — US disclosed
CN-102272114-A Photochromic compounds — 2011-12-07 — — CN disclosed
EP-2370420-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2011-10-05 — — EP disclosed
WO-2010065393-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2010-06-10 — — WO disclosed
US-20090309076-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2009-12-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180291007-A1 Photochromic Compounds CCR4, CCR8, CBR3 NR4A2 108/4885L3MBTL1 2464/4885CHEK1 161/4885
US-20160332995-A1 Photochromic Comounds CCR4, CCR3, CCR8 NR4A2 162/4885L3MBTL1 2408/4885CHEK1 91/4885
US-10005763-B2 Photochromic compounds CCR4, CCR8, CBR3 NR4A2 108/4885L3MBTL1 2456/4885CHEK1 160/4885
US-20180291008-A1 Photochromic Compounds CCR4, CBR3, CCR8 NR4A2 103/4885L3MBTL1 2227/4885CHEK1 190/4885
US-20160333262-A1 Photochromic Compounds CCR4, CCR8, CBR3 NR4A2 108/4885L3MBTL1 2456/4885CHEK1 160/4885
US-20180291009-A1 Photochromic Compounds CCR4, CCR8, CBR3 NR4A2 110/4885L3MBTL1 2454/4885CHEK1 166/4885
US-10000472-B2 Photochromic compounds CCR4, CCR8, CBR3 NR4A2 108/4885L3MBTL1 2456/4885CHEK1 160/4885
US-20120200907-A1 PHOTOCHROMIC COMPOUNDS CCR4, CCR8, CBR3 NR4A2 113/4885L3MBTL1 2421/4885CHEK1 176/4885
US-20090309076-A1 PHOTOCHROMIC COMPOUNDS CCR4, CCR8, CBR3 NR4A2 108/4885L3MBTL1 2456/4885CHEK1 160/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.