SCHEMBL6172886

SCHEMBL6172886

COC(=O)c1cc(O)c2cc(OC)ccc2c1C

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 1/20 0.51
KDM4E B2RXH2 4/20 0.48
CYP1A2 P05177 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
CA1 P00915 3/20 0.46
CA2 P00918 3/20 0.46
NPC1 O15118 3/20 0.46
RAB9A P51151 3/20 0.46
CA12 O43570 2/20 0.46
CA7 P43166 2/20 0.46
CA9 Q16790 2/20 0.46
CA14 Q9ULX7 2/20 0.46
PLA2G2A P14555 3/20 0.46
HPGD P15428 4/20 0.45
ALDH1A1 P00352 3/20 0.45
CYP3A4 P08684 2/20 0.45
MAPK1 P28482 1/20 0.45
ESR2 Q92731 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6652410 0.86 KDM4E (0.52) KDM4ECYP1A2CYP2D6CYP2C19CA1
SCHEMBL7791035 0.82 NR4A2 (0.43) NR4A2KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL2470133 0.81 LMNA (0.55) NR4A2KDM4ECA1CA2CA12
SCHEMBL8184663 0.80 NR4A2 (0.47) NR4A2KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL6655670 0.77 CES2 (0.58) KDM4ENPC1RAB9AHPGDALDH1A1
SCHEMBL2469996 0.76 NR4A2 (0.51) NR4A2CA1CA2CA12CA7
SCHEMBL6480627 0.75 GAA (0.44) NR4A2KDM4ECYP1A2CYP2D6CYP2C9
Methyl 2-Hydroxy-5-Methoxybenzoate SCHEMBL643758 0.75 CA1 (0.72) NR4A2KDM4ECYP1A2CYP2D6CYP2C9
Methyl 2-Hydroxy-5-Methoxybenzoate SCHEMBL29709382 0.75 CA1 (0.72) NR4A2KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL294143 0.75 CA12 (0.72) NR4A2KDM4ECYP1A2CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1112263-B1 POLYMERIZABLE POLYALKOXYLATED NAPHTHOPYRANS TRANSITIONS OPTICAL INC (US) 2005-06-08 EP disclosed
EP-0835870-B1 Photochromic substituted naphthopyrans PPG IND OHIO INC (US) 2004-03-03 EP disclosed
EP-1112263-A1 POLYMERIZABLE POLYALKOXYLATED NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 2001-07-04 EP disclosed
US-6113814-A PHOTOCHROMIC; END-CAPPED WITH A POLYMERIZABLE GROUP. TRANSITIONS OPTICAL, INC. (US) 2000-09-05 US disclosed
US-6087304-A ANTIARRHYTHMIC PHARMACEUTICALS HAVING A CARDIOPROTECTIVE COMPONENT FOR INFARCT PROPHYLAXIS AND INFARCT TREATMENT AND FOR THE TREATMENT OF ANGINA PECTORIS HOECHST AKTIENGESELLSCHAFT (DE) 2000-07-11 US disclosed
WO-2000015629-A1 POLYMERIZABLE POLYALKOXYLATED NAPHTHOPYRANS PPG INDUSTRIES OHIO, INC. (US) 2000-03-23 WO disclosed
EP-0835870-A1 Photochromic substituted naphthopyrans PPG INDUSTRIES, INC. (US) 1998-04-15 EP disclosed
WO-1998014443-A1 NOVEL SUBSTITUTED NAPHTHOPYRANS PPG INDUSTRIES, INC. (US) 1998-04-09 WO disclosed
US-5656206-A OPHTHALIMIC LENSES; RADIATION TRANSPARENT; PHOTOCHROMISM TRANSITIONS OPTICAL, INC. (US) 1997-08-12 US disclosed
US-5573712-A PHOTOCHROMIC ARTICLE COMPRISING ORGANIC HOST AND THE PHOTOCHROMIC NAPHTHOPYRAN TRANSITIONS OPTICAL, INC. (US) 1996-11-12 US disclosed
US-5458814-A Ophthalmic lenses TRANSITIONS OPTICAL, INC. (US) 1995-10-17 US disclosed