Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437045 | 0.84 | L3MBTL1 (0.40) | DRD4DRD3L3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL3653746 | 0.81 | DRD4 (0.57) | DRD4DRD3L3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL14047371 | 0.81 | DRD4 (0.43) | DRD4DRD3L3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL19331490 | 0.78 | ALDH1A1 (0.40) | DRD4DRD3L3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL4432949 | 0.77 | DRD4 (0.40) | DRD4DRD3L3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL23747875 | 0.76 | MPO (0.40) | DRD4DRD3L3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL23171051 | 0.72 | ALDH1A1 (0.33) | DRD4DRD3L3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL12970079 | 0.71 | MBNL1 (0.40) | DRD4DRD3L3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL7435 | 0.71 | TAAR1 (0.49) | DRD4DRD3L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL2721091 | 0.71 | PARP1 (0.36) | CYP2D6KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834231-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013152150-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-10-10 | — | — | WO | disclosed |
| EP-2588469-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003271-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |