Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.73 |
| ▸ | NOS1 | P29475 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | SLC22A2 | O15244 | 6/20 | 0.52 |
| ▸ | SLC22A1 | O15245 | 6/20 | 0.52 |
| ▸ | SLC22A3 | O75751 | 6/20 | 0.52 |
| ▸ | PLAU | P00749 | 5/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.52 |
| ▸ | HTR3B | O95264 | 3/20 | 0.52 |
| ▸ | HTR3A | P46098 | 3/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5005289 | 0.78 | NOS3 (0.67) | NOS3NOS1CA12CA2CA9 | |
| SCHEMBL5005292 | 0.78 | NOS3 (0.67) | NOS3NOS1CA12CA2CA9 | |
| SCHEMBL9529527 | 0.77 | NOS3 (0.59) | NOS3NOS1CA12CA1CA2 | |
| Iodide SCHEMBL10519588 | 0.77 | NOS3 (0.65) | NOS3NOS1MEN1KMT2A | |
| SCHEMBL21799345 | 0.75 | PRSS1 (0.54) | NOS3NOS1POLBSLC22A2SLC22A1 | |
| SCHEMBL2035942 | 0.74 | NOS3 (0.57) | NOS3NOS1CA12CA1CA2 | |
| SCHEMBL17396097 | 0.74 | CYP2D6 (0.62) | NOS3NOS1CA1CA2SLC22A2 | |
| SCHEMBL7048572 | 0.73 | NOS3 (0.56) | NOS3NOS1CA12CA1CA2 | |
| SCHEMBL15058734 | 0.72 | NOS3 (0.66) | NOS3NOS1CA12CA1CA2 | |
| SCHEMBL15058732 | 0.72 | NOS3 (0.66) | NOS3NOS1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119931524-A | Special purpose composite waterproof coiled material and production process thereof | 北京宇阳泽丽防水材料有限责任公司 | 2025-05-06 | — | — | CN | claimed |
| CN-119931524-A | Special purpose composite waterproof coiled material and production process thereof | 北京宇阳泽丽防水材料有限责任公司 | 2025-05-06 | — | — | CN | disclosed |
| EP-3621952-A1 | METHOD FOR THE PRODUCTION OF PHENYLGUANIDINES OR THE SALTS THEREOF | AlzChem Trostberg GmbH (DE) | 2020-03-18 | — | — | EP | disclosed |
| WO-2018210633-A1 | METHOD FOR THE PRODUCTION OF PHENYLGUANIDINES OR THE SALTS THEREOF | ALZCHEM TROSTBERG GMBH (DE) | 2018-11-22 | — | — | WO | disclosed |
| CN-103373965-B | The preparation method of etravirine and intermediate thereof | SHANGHAI DESANO PHARMACEUTICAL CO.,LTD. (CN) | 2016-04-27 | — | — | CN | disclosed |
| EP-2342186-B1 | PROCESS FOR SYNTHESIS OF ETRAVIRINE | EMCURE PHARMACEUTICALS LTD (IN) | 2014-09-17 | — | — | EP | disclosed |
| US-8618291-B2 | Process for preparing 4-[(1,6-dihydro-6-OXO-2-pyrimidinyl)amino]benzonitrile | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2013-12-31 | — | — | US | disclosed |
| EP-2655340-A1 | BI-HETEROARYL COMPOUNDS AS VPS34 INHIBITORS | Novartis AG (CH) | 2013-10-30 | — | — | EP | disclosed |
| CN-103373965-A | Preparation methods of etravirine and intermediate body thereof | SHANGHAI DESANO PHARMACEUTICAL CO LTD | 2013-10-30 | — | — | CN | disclosed |
| EP-1888537-B1 | PROCESS FOR PREPARING 4-[(1,6-DIHYDRO-6-OXO-2-PYRIMIDINYL)AMINO BENZONITRILE | JANSSEN R & D IRELAND (IE) | 2013-09-11 | — | — | EP | disclosed |
| US-20120083606-A1 | PROCESS FOR PREPARING 4-[(1,6-DIHYDRO-6-OXO-2-PYRIMIDINYL)AMINO]BENZONITRILE | JANSSEN SCIENCES IRELAND UC (IE) | 2012-04-05 | — | — | US | disclosed |
| US-8101752-B2 | Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2012-01-24 | — | — | US | disclosed |
| WO-2012001695-A1 | A PROCESS FOR ETRA VIRINE INTERMEDIATE AND POLYMORPHS OF ETRAVIRINE | HETERO RESEARCH FOUNDATION (IN) | 2012-01-05 | — | — | WO | disclosed |
| US-20110196156-A1 | PROCESS FOR SYNTHESIS OF DIARYLPYRIMIDINE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR | GURJAR MUKUND KESHAV | 2011-08-11 | — | — | US | disclosed |
| EP-2342186-A2 | PROCESS FOR SYNTHESIS OF DIARYLPYRIMIDINE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR | Emcure Pharmaceuticals Limited (IN) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010150279-A2 | PROCESS FOR SYNTHESIS OF DIARYLPYRIMIDINE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR | EMCURE PHARMACEUTICALS LIMITED (IN) | 2010-12-29 | — | — | WO | disclosed |
| US-20080171878-A1 | Process for Preparing 4-[(1,6-Dihydro-6-Oxo-2-Pyrimidinyl)Amino]Benzonitrile | JANSSEN SCIENCES IRELAND UC (IE) | 2008-07-17 | — | — | US | disclosed |
| EP-1888537-A1 | PROCESS FOR PREPARING 4-[(1,6-DIHYDRO-6-OXO-2-PYRIMIDINYL)AMINO BENZONITRILE | Tibotec Pharmaceuticals Ltd. (IE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006125809-A1 | PROCESS FOR PREPARING 4-[(1,6-DIHYDRO-6-OXO-2-PYRIMIDINYL)AMINO BENZONITRILE | TIBOTEC PHARMACEUTICALS LTD (IE) | 2006-11-30 | — | — | WO | disclosed |
| EP-0392802-A2 | Preparation of urea analogues and their use in bronchial, cerebrovascular and neuronal disorders | Beecham Group p.l.c. (GB) | 1990-10-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171878-A1 | Process for Preparing 4-[(1,6-Dihydro-6-Oxo-2-Pyrimidinyl)Amino]Benzonitrile | ME1, ALKBH1, DPYD | NOS3 3946/4885NOS1 1657/4885POLB 177/4885 |
| US-20120083606-A1 | PROCESS FOR PREPARING 4-[(1,6-DIHYDRO-6-OXO-2-PYRIMIDINYL)AMINO]BENZONITRILE | ME1, ALKBH1, DPYD | NOS3 3946/4885NOS1 1657/4885POLB 177/4885 |
| US-20110196156-A1 | PROCESS FOR SYNTHESIS OF DIARYLPYRIMIDINE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR | TYMP, DPYD, POLR2H | NOS3 3335/4885NOS1 3359/4885POLB 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.