SCHEMBL2470697

SCHEMBL2470697

C[Si](C)(C)C#Cc1ccccc1Br

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.42
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
MAPT P10636 1/20 0.42
CYP2C9 P11712 1/20 0.42
HPGD P15428 1/20 0.42
TSHR P16473 1/20 0.42
CYP2C19 P33261 1/20 0.42
KMT2A Q03164 1/20 0.42
HSD17B10 Q99714 1/20 0.42
FFAR1 O14842 1/20 0.36
CREBBP Q92793 1/20 0.35
GRM5 P41594 2/20 0.30
KCNH2 Q12809 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3839029 0.84 KDM4E (0.49) ALDH1A1KDM4EMEN1CYP1A2CYP3A4
SCHEMBL20912024 0.82 ALDH1A1 (0.36) ALDH1A1KDM4EMEN1CYP1A2CYP3A4
SCHEMBL23529810 0.80 KDM4E (0.36) ALDH1A1KDM4EMEN1CYP1A2CYP3A4
SCHEMBL30468202 0.78 FFAR1 (0.47) ALDH1A1KDM4EMEN1CYP1A2CYP3A4
SCHEMBL2466535 0.78 FFAR1 (0.47) ALDH1A1KDM4EMEN1CYP1A2CYP3A4
SCHEMBL1626253 0.78 FFAR1 (0.36) ALDH1A1TSHRFFAR1
SCHEMBL10535351 0.77 TSHR (0.45) ALDH1A1KDM4EMEN1CYP1A2CYP3A4
SCHEMBL31562390 0.76 CREBBP (0.35) ALDH1A1KDM4EMEN1CYP1A2CYP3A4
SCHEMBL31349196 0.76 TSHR (0.48) ALDH1A1KDM4EMEN1CYP1A2CYP3A4
SCHEMBL1324387 0.76 TSHR (0.48) ALDH1A1KDM4EMEN1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250243229-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2025-07-31 US disclosed
US-12297212-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2025-05-13 US disclosed
EP-4489555-A2 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES Universal Display Corporation (US) 2025-01-08 EP disclosed
EP-3539959-B1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORP (US) 2024-12-11 EP disclosed
CN-115583902-B Preparation method of alkynyl thioether compound 江苏医药职业学院 2024-02-13 CN disclosed
US-20230365607-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-11-16 US disclosed
US-20230365607-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-11-16 US disclosed
US-20230365607-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-11-16 US disclosed
US-11746122-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-09-05 US disclosed
US-11746122-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-09-05 US disclosed
US-9006503-B2 Organic electroluminescence devices containing substituted benzo[C]phenanthrenes MERCK PATENT GMBH (DE) 2015-04-14 US disclosed
US-20140155415-A1 BENZODIOXEPINE AND BENZODIOXINE COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES AMGEN INC. 2014-06-05 US disclosed
US-8710284-B2 Materials for organic electroluminescent devices containing substituted 10-benzo[c]phenanthrenes MERCK PATENT GMBH (DE) 2014-04-29 US disclosed
US-8710284-B2 Materials for organic electroluminescent devices containing substituted 10-benzo[c]phenanthrenes MERCK PATENT GMBH (DE) 2014-04-29 US disclosed
EP-2694491-A1 BENZODIOXEPINE AND BENZODIOXINE COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES Amgen Inc. (US) 2014-02-12 EP disclosed
WO-2012138776-A1 BENZODIOXEPINE AND BENZODIOXINE COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES AMGEN INC. (US) 2012-10-11 WO disclosed
US-20110288292-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENCE DEVICES MERCK PATENT GMBH (DE) 2011-11-24 US disclosed
EP-2371829-A1 Method for producing benzo-trithiophene or benzo-triselenophene derivatives Nippon Kayaku Kabushiki Kaisha (JP) 2011-10-05 EP disclosed
US-20100137617-A1 METHOD FOR PRODUCING AROMATIC COMPOUND NIPPON KAYAKU KABUSHIKI KAISHA (JP) 2010-06-03 US disclosed
EP-2147923-A1 METHOD FOR PRODUCING AROMATIC COMPOUND Nippon Kayaku Kabushiki Kaisha (JP) 2010-01-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110288292-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENCE DEVICES DDT, DDC, BMI1 ALDH1A1 356/4885KDM4E 1250/4885MEN1 1428/4885
US-11746122-B2 Organic electroluminescent materials and devices GLRA3, GLRA2, LIFR ALDH1A1 4154/4885KDM4E 1677/4885MEN1 2878/4885
US-20250243229-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES F5, OR10J3, NPY4R ALDH1A1 1417/4885KDM4E 1449/4885MEN1 908/4885
US-12297212-B2 Organic electroluminescent materials and devices OCIAD2, OCIAD1, OR10J3 ALDH1A1 2211/4885KDM4E 3068/4885MEN1 989/4885
US-20100137617-A1 METHOD FOR PRODUCING AROMATIC COMPOUND SCLY, TYR, CBS ALDH1A1 716/4885KDM4E 3311/4885MEN1 769/4885
US-20230365607-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD2, OCIAD1, OR10J3 ALDH1A1 2211/4885KDM4E 3068/4885MEN1 989/4885
US-20140155415-A1 BENZODIOXEPINE AND BENZODIOXINE COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES GCKR, GCK, PDK2 ALDH1A1 3327/4885KDM4E 704/4885MEN1 4464/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.