Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24712657 | 0.86 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1KDM4EMAPK1GBA1 | |
| SCHEMBL24712352 | 0.80 | CYP1A2 (0.37) | SMN1; SMN2ALDH1A1KDM4EMAPK1MAPT | |
| SCHEMBL2726482 | 0.80 | HRH4 (0.50) | SMN1; SMN2ALDH1A1KDM4EMAPK1MAPT | |
| SCHEMBL24712889 | 0.80 | PTGS2 (0.39) | — | |
| SCHEMBL24712656 | 0.78 | PTGS2 (0.35) | SMN1; SMN2ALDH1A1KDM4EALOX15HPGD | |
| SCHEMBL24711975 | 0.75 | PRKCH (0.35) | SMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL9404476 | 0.74 | KDM4E (0.50) | SMN1; SMN2ALDH1A1KDM4EMAPK1MAPT | |
| SCHEMBL25081570 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1KDM4EMAPK1GBA1 | |
| SCHEMBL16166887 | 0.73 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1KDM4EMAPK1MAPT | |
| SCHEMBL30742492 | 0.72 | ALDH1A1 (0.51) | ALDH1A1KDM4EMAPK1GBA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240287078-A1 | QUINAZOLINE DERIVATIVES USEFUL AS RAS INHIBITORS | REDX PHARMA PLC (GB) | 2024-08-29 | — | — | US | disclosed |
| EP-4352061-A1 | QUINAZOLINE DERIVATIVES USEFUL AS RAS INHIBITIORS | Redx Pharma Plc (GB) | 2024-04-17 | — | — | EP | disclosed |
| CN-117425658-A | Quinazoline derivatives as RAS inhibitors | 莱德克斯制药公共有限公司 | 2024-01-19 | — | — | CN | disclosed |
| WO-2022258974-A1 | QUINAZOLINE DERIVATIVES USEFUL AS RAS INHIBITIORS | REDX PHARMA PLC (GB) | 2022-12-15 | — | — | WO | disclosed |
| WO-2022258974-A1 | QUINAZOLINE DERIVATIVES USEFUL AS RAS INHIBITIORS | REDX PHARMA PLC (GB) | 2022-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240287078-A1 | QUINAZOLINE DERIVATIVES USEFUL AS RAS INHIBITORS | KRAS, NRAS, HRAS | SMN1; SMN2 4726/4885ALDH1A1 3891/4885KDM4E 3121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.