Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24712889 | 0.83 | PTGS2 (0.39) | PTGS2RORC | |
| SCHEMBL24711986 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2PIK3CAKDM4EALDH1A1HPGD | |
| SCHEMBL24712653 | 0.73 | TUBB4A (0.33) | PTGS2SMN1; SMN2ALDH1A1 | |
| SCHEMBL24712352 | 0.70 | CYP1A2 (0.37) | SMN1; SMN2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL24711975 | 0.68 | PRKCH (0.35) | SMN1; SMN2KDM4EALDH1A1MBOAT4 | |
| SCHEMBL24711969 | 0.66 | EPRS1 (0.38) | — | |
| SCHEMBL2726482 | 0.65 | HRH4 (0.50) | SMN1; SMN2PIK3CAKDM4EALDH1A1HPGD | |
| SCHEMBL24712657 | 0.64 | SMN1; SMN2 (0.41) | SMN1; SMN2PIK3CAKDM4EALDH1A1HPGD | |
| SCHEMBL1284337 | 0.60 | PIK3CA (0.46) | SMN1; SMN2PIK3CAKDM4EALDH1A1ALOX15 | |
| SCHEMBL16166887 | 0.60 | SMN1; SMN2 (0.50) | SMN1; SMN2KDM4EALDH1A1HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4352061-A1 | QUINAZOLINE DERIVATIVES USEFUL AS RAS INHIBITIORS | Redx Pharma Plc (GB) | 2024-04-17 | — | — | EP | disclosed |
| CN-117425658-A | Quinazoline derivatives as RAS inhibitors | 莱德克斯制药公共有限公司 | 2024-01-19 | — | — | CN | disclosed |
| WO-2022258974-A1 | QUINAZOLINE DERIVATIVES USEFUL AS RAS INHIBITIORS | REDX PHARMA PLC (GB) | 2022-12-15 | — | — | WO | disclosed |
| WO-2022258974-A1 | QUINAZOLINE DERIVATIVES USEFUL AS RAS INHIBITIORS | REDX PHARMA PLC (GB) | 2022-12-15 | — | — | WO | disclosed |