SCHEMBL247124

SCHEMBL247124

CC(C)(C)OC(=O)COc1ccc(C(=O)Cc2ccccc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 1/20 0.51
STS P08842 1/20 0.50
L3MBTL1 Q9Y468 3/20 0.48
LMNA P02545 2/20 0.48
MAPK1 P28482 2/20 0.48
CASP3 P42574 1/20 0.48
SENP7 Q9BQF6 1/20 0.48
SENP6 Q9GZR1 1/20 0.48
MAPT P10636 3/20 0.48
NPC1 O15118 2/20 0.48
RAB9A P51151 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
PLA2G4B P0C869 1/20 0.48
KMT2A Q03164 1/20 0.47
SRD5A2 P31213 2/20 0.47
PPARG P37231 1/20 0.45
PPARA Q07869 1/20 0.45
HRH2 P25021 1/20 0.45
HRH1 P35367 1/20 0.45
MAOB P27338 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1047069 0.83 PPARA (0.56) PTPN1L3MBTL1LMNAMAPK1MAPT
SCHEMBL8315900 0.83 L3MBTL1 (0.49) PTPN1L3MBTL1LMNAMAPK1CASP3
SCHEMBL2448079 0.82 ALOX15 (0.57) PTPN1LMNACASP3SENP7SENP6
SCHEMBL8315903 0.82 ALDH1A1 (0.51) PTPN1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL1968491 0.82 KMT2A (0.55) PTPN1L3MBTL1LMNAMAPK1MAPT
SCHEMBL12697639 0.82 ALDH1A1 (0.59) PTPN1L3MBTL1LMNAMAPK1MAPT
SCHEMBL12697638 0.81 PLA2G4B (0.56) PTPN1NPC1RAB9ASMN1; SMN2PLA2G4B
SCHEMBL1964630 0.81 PLA2G4B (0.61) PTPN1MAPK1PLA2G4BSRD5A2
SCHEMBL8558071 0.80 AOC3 (0.47) PTPN1L3MBTL1LMNAMAPTNPC1
SCHEMBL7332590 0.80 GSK3B (0.54) PTPN1L3MBTL1LMNAMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150157605-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES JENRIN DISCOVERY, INC. 2015-06-11 US disclosed
US-8853252-B2 Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes JENRIN DISCOVERY, INC. (US) 2014-10-07 US disclosed
US-8648072-B2 Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes JENRIN DISCOVERY, INC. (US) 2014-02-11 US disclosed
EP-2203061-B1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES JENRIN DISCOVERY (US) 2013-12-18 EP disclosed
US-8580768-B2 Cannabinoid receptor antagonists-inverse agonists useful for treating metabolic disorders, including obesity and diabetes JENRIN DISCOVERY, INC. (US) 2013-11-12 US disclosed
EP-2640381-A2 CANNABINOID RECEPTOR ANTAGONISTS-INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES Jenrin Discovery (US) 2013-09-25 EP disclosed
US-20130005784-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES JENRIN DISCOVERY (US) 2013-01-03 US disclosed
US-20120264754-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES JENRIN DISCOVERY (US) 2012-10-18 US disclosed
US-20120264797-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES JENRIN DISCOVERY (US) 2012-10-18 US disclosed
US-8217038-B2 Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes JENRIN DISCOVERY, INC. (US) 2012-07-10 US disclosed
EP-2203061-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES Jenrin Discovery (US) 2010-07-07 EP disclosed
US-20100152260-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES JENRIN DISCOVERY (US) 2010-06-17 US disclosed
US-20100105751-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES JENRIN DISCOVERY (US) 2010-04-29 US disclosed
US-7666889-B2 Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes JENRIN DISCOVERY, INC. (US) 2010-02-23 US disclosed
US-7655685-B2 Cardiometabolic disorders like obesity, diabetes, hypertension and dyslipidemias, 3, 4-diarylpyrazole derivatives; highly selective; limited or no CNS adverse side effects, including mood disorders JENRIN DISCOVERY, INC. (US) 2010-02-02 US disclosed
WO-2009059264-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES JENRIN DISCOVERY (US) 2009-05-07 WO disclosed
US-20090118345-A1 Cardiometabolic disorders like obesity, diabetes, hypertension and dyslipidemias, 3, 4-diarylpyrazole derivatives; highly selective; limited or no CNS adverse side effects, including mood disorders JENRIN DISCOVERY (US) 2009-05-07 US disclosed
US-20090036511-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES JENRIN DISCOVERY (US) 2009-02-05 US disclosed
US-7482470-B2 Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes JENRIN DISCOVERY, INC. (US) 2009-01-27 US disclosed
US-20070259934-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES JENRIN DISCOVERY (US) 2007-11-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130005784-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES CNR2, CNR1, GPR119 PTPN1 1598/4885STS 2556/4885L3MBTL1 4387/4885
US-20090118345-A1 Cardiometabolic disorders like obesity, diabetes, hypertension and dyslipidemias, 3, 4-diarylpyrazole derivatives; highly selective; limited or no CNS adverse side effects, including mood disorders CNR2, CNR1, GPR119 PTPN1 876/4885STS 3820/4885L3MBTL1 3142/4885
US-20120264754-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES CNR2, CNR1, GPR119 PTPN1 1385/4885STS 3603/4885L3MBTL1 4419/4885
US-20070259934-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES CNR2, CNR1, GPR119 PTPN1 1598/4885STS 2556/4885L3MBTL1 4387/4885
US-20100105751-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES CNR2, CNR1, GPR119 PTPN1 1711/4885STS 2683/4885L3MBTL1 4275/4885
US-20120264797-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES CNR2, CNR1, GPR119 PTPN1 1711/4885STS 2683/4885L3MBTL1 4275/4885
US-20090036511-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES CNR2, CNR1, GPR119 PTPN1 1598/4885STS 2556/4885L3MBTL1 4387/4885
US-20100152260-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES CNR2, CNR1, GPR119 PTPN1 1598/4885STS 2556/4885L3MBTL1 4387/4885
US-20150157605-A1 CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES CNR2, CNR1, GPR119 PTPN1 1711/4885STS 2683/4885L3MBTL1 4275/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.