Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MT-CO2 | P00403 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2474850 | 0.90 | NPC1 (0.46) | PTGS2PTGS1MAPK14KMT2AMEN1 | |
| SCHEMBL2470928 | 0.89 | MAPK14 (0.48) | PTGS2PTGS1MAPK14KMT2AGAA | |
| SCHEMBL2472497 | 0.80 | MAPK14 (0.49) | PTGS2PTGS1MAPK14KMT2AMEN1 | |
| SCHEMBL2470836 | 0.80 | MAPK14 (0.48) | PTGS2PTGS1MAPK14KMT2AMEN1 | |
| SCHEMBL2473829 | 0.79 | DHODH (0.45) | PTGS2PTGS1MAPK14ALDH1A1MAPT | |
| SCHEMBL4509398 | 0.75 | ALDH1A1 (0.50) | PTGS2PTGS1MAPK14KMT2AMEN1 | |
| SCHEMBL2469050 | 0.75 | MAPT (0.46) | PTGS2PTGS1MAPK14KMT2AGAA | |
| SCHEMBL2472887 | 0.74 | PTGS1 (0.48) | PTGS2PTGS1MAPK14KMT2AMEN1 | |
| SCHEMBL2471999 | 0.74 | PTGS2 (0.45) | PTGS2PTGS1MAPK14KMT2AMEN1 | |
| SCHEMBL2472255 | 0.73 | PTGS2 (0.52) | PTGS2PTGS1MAPK14KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968973-B1 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-10-05 | — | — | EP | claimed |