Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MT-CO2 | P00403 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2470928 | 0.83 | MAPK14 (0.48) | MAPK14PTGS2PTGS1ALDH1A1MAPK8 | |
| SCHEMBL2474038 | 0.82 | MAPT (0.44) | MAPK14PTGS2PTGS1MAPTTDP1 | |
| SCHEMBL2471679 | 0.80 | PTGS2 (0.50) | MAPK14PTGS2PTGS1ALDH1A1MAPK8 | |
| SCHEMBL2470836 | 0.74 | MAPK14 (0.48) | MAPK14PTGS2PTGS1ALDH1A1MAPK8 | |
| SCHEMBL2469050 | 0.72 | MAPT (0.46) | MAPK14PTGS2PTGS1ALDH1A1MT-CO2 | |
| SCHEMBL2474850 | 0.72 | NPC1 (0.46) | MAPK14PTGS2PTGS1ALDH1A1MAPK8 | |
| SCHEMBL4495802 | 0.71 | ALDH1A1 (0.58) | MAPK14PTGS2PTGS1ALDH1A1MT-CO2 | |
| SCHEMBL2470784 | 0.70 | MAPK14 (0.42) | MAPK14PTGS2PTGS1MAPK8MAPT | |
| SCHEMBL2473829 | 0.70 | DHODH (0.45) | MAPK14PTGS2PTGS1ALDH1A1MAPT | |
| SCHEMBL2472887 | 0.70 | PTGS1 (0.48) | MAPK14PTGS2PTGS1ALDH1A1MT-CO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968973-B1 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-10-05 | — | — | EP | claimed |