Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29479185 | 0.91 | ALDH1A1 (0.51) | ALDH1A1TSHRCYP3A4CYP1A2RECQL | |
| SCHEMBL1828398 | 0.91 | ALDH1A1 (0.51) | ALDH1A1TSHRCYP3A4CYP1A2RECQL | |
| SCHEMBL29525219 | 0.89 | ALDH1A1 (0.53) | ALDH1A1TSHRCYP3A4CYP1A2RECQL | |
| SCHEMBL440478 | 0.89 | ALDH1A1 (0.53) | ALDH1A1TSHRCYP3A4CYP1A2RECQL | |
| SCHEMBL29805163 | 0.87 | TDP1 (0.50) | ALDH1A1TSHRCYP3A4CYP1A2RECQL | |
| SCHEMBL187542 | 0.87 | TDP1 (0.50) | ALDH1A1TSHRCYP3A4CYP1A2RECQL | |
| SCHEMBL397387 | 0.87 | ATM (0.50) | ALDH1A1TSHRCYP3A4CYP1A2RECQL | |
| SCHEMBL107162 | 0.87 | TDP1 (0.50) | ALDH1A1TSHRCYP3A4CYP1A2RECQL | |
| SCHEMBL8053279 | 0.86 | TSHR (0.58) | ALDH1A1TSHRCYP3A4CYP1A2RECQL | |
| SCHEMBL12593915 | 0.84 | TDP1 (0.52) | ALDH1A1TSHRCYP3A4CYP1A2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724190-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LTD (IN) | 2022-07-06 | — | — | EP | disclosed |
| CN-113302178-A | Diamine, polyimide derived therefrom, and molded article thereof | 本州化学工业株式会社 | 2021-08-24 | — | — | CN | disclosed |
| US-20210163486-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2021-06-03 | — | — | US | disclosed |
| WO-2020158523-A1 | NOVEL DIAMINE, NOVEL POLYIMIDE DERIVED THEREFROM, AND MOLDED BODY THEREOF | 本州化学工業株式会社 | 2020-08-06 | — | — | WO | disclosed |
| WO-2019116302-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2019-06-20 | — | — | WO | disclosed |
| US-9499555-B2 | Porous crystalline frameworks, process for the preparation therof and their mechanical delamination to covalent organic nanosheets (CONS) | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2016-11-22 | — | — | US | disclosed |
| US-9387202-B2 | Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities | DECIPHERA PHARMACEUTICALS, LLC (US) | 2016-07-12 | — | — | US | disclosed |
| US-9181245-B2 | Substituted pyrido[1,2-a]pyrazines and substituted pyrido[1,2-a][1,4]diazepines for the treatment of (inter alia) Alzheimer's disease | Janssen Pharmaceuticals, Inc. (US) | 2015-11-10 | — | — | US | disclosed |
| US-20150297738-A1 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2015-10-22 | — | — | US | disclosed |
| US-20150148380-A1 | PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | DECIPHERA PHARMACEUTICALS, LLC | 2015-05-28 | — | — | US | disclosed |
| US-20090047251-A1 | Conjugates of hydroxyalkyl starch and a protein | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2009-02-19 | — | — | US | disclosed |
| WO-2008155033-A1 | SUBSTITUTED (OXAZOLIDINON-5-YL-METHYL) -2-THIOPHENE-CARBOXAMIDES AND USE THEREOF IN THE FIELD OF BLOOD COAGULATION | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008155032-A1 | SUBSTITUTED (OXAZOLIDINON-5-YL-METHYL) -2-THIOPHENE-CARBOXAMIDES AND USE THEREOF IN THE FIELD OF BLOOD COAGULATION | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008155069-A2 | SUBSTITUTED OXAZOLIDINONES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-12-24 | — | — | WO | disclosed |
| US-20080274948-A1 | Conjugates of Hydroxyalkyl Starch and G-Csf | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2008-11-06 | — | — | US | disclosed |
| US-20080207562-A1 | Conjugates of Hydroxyalkyl Starch and Active Substance, Prepared by Chemical Ligation Via Thiazolidine | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2008-08-28 | — | — | US | disclosed |
| US-20080206182-A1 | Conjugates of a Polymer and a Protein Linked by an Oxime Group | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2008-08-28 | — | — | US | disclosed |
| US-20070134197-A1 | Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2007-06-14 | — | — | US | disclosed |
| CN-1053666-C | Benzoheterocyclic compounds | OTSUKA PHARMA CO LTD (JP) | 2000-06-21 | — | — | CN | disclosed |
| CN-1030237-A | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1989-01-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080274948-A1 | Conjugates of Hydroxyalkyl Starch and G-Csf | CSF3R, CCL11, CSF1R | ALDH1A1 2536/4885TSHR 3999/4885CYP3A4 3658/4885 |
| US-20150148380-A1 | PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | MKI67, TYMP, CCNA1 | ALDH1A1 250/4885TSHR 2946/4885CYP3A4 2008/4885 |
| US-20080206182-A1 | Conjugates of a Polymer and a Protein Linked by an Oxime Group | LPO, DAO, DNPEP | ALDH1A1 1565/4885TSHR 2741/4885CYP3A4 704/4885 |
| US-20210163486-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT3 | ALDH1A1 2553/4885TSHR 3684/4885CYP3A4 1372/4885 |
| US-20090047251-A1 | Conjugates of hydroxyalkyl starch and a protein | CHLSN, STT3A, PA2G4 | ALDH1A1 3779/4885TSHR 4134/4885CYP3A4 3793/4885 |
| US-20070134197-A1 | Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination | DERA, HBG1, HACL2 | ALDH1A1 478/4885TSHR 4559/4885CYP3A4 724/4885 |
| US-20080207562-A1 | Conjugates of Hydroxyalkyl Starch and Active Substance, Prepared by Chemical Ligation Via Thiazolidine | HACL2, AGL, TTL | ALDH1A1 312/4885TSHR 796/4885CYP3A4 343/4885 |
| US-20150297738-A1 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION | HASPIN, HACL2, PCNA | ALDH1A1 1139/4885TSHR 4392/4885CYP3A4 1227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.