Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.49 |
| ▸ | RXRB | P28702 | 5/20 | 0.49 |
| ▸ | RXRG | P48443 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | USP1 | O94782 | 10/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30146258 | 0.88 | KDM4E (0.44) | CYP2C9PTGS2USP1 | |
| SCHEMBL31496709 | 0.86 | USP1 (0.45) | USP1SYK | |
| SCHEMBL25792585 | 0.85 | RXRA (0.46) | RXRARXRBRXRGCYP2C9PTGS2 | |
| SCHEMBL22122030 | 0.83 | USP1 (0.45) | USP1 | |
| SCHEMBL31138700 | 0.82 | PTGS2 (0.44) | RXRARXRBRXRGPTGS2USP1 | |
| SCHEMBL6365685 | 0.82 | USP1 (0.46) | USP1 | |
| SCHEMBL22122099 | 0.81 | USP1 (0.46) | PTGS2USP1 | |
| SCHEMBL24718555 | 0.81 | DGAT1 (0.48) | RXRARXRBRXRGDGAT1 | |
| SCHEMBL30816574 | 0.81 | FFAR1 (0.45) | CYP2C9USP1 | |
| SCHEMBL22122019 | 0.80 | USP1 (0.50) | USP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117412973-A | Nitrogen-containing fused heteroaromatic bicyclic compounds as USP1 inhibitors and uses thereof | 上海瑛派药业有限公司 | 2024-01-16 | — | — | CN | disclosed |
| WO-2022253188-A1 | NITROGEN-CONTAINING FUSED HETEROAROMATIC BICYCLIC COMPOUNDS AS USP1 INHIBITORS AND THE USE THEREOF | IMPACT THERAPEUTICS (SHANGHAI) , INC (CN) | 2022-12-08 | — | — | WO | disclosed |
| WO-2022253188-A1 | NITROGEN-CONTAINING FUSED HETEROAROMATIC BICYCLIC COMPOUNDS AS USP1 INHIBITORS AND THE USE THEREOF | IMPACT THERAPEUTICS (SHANGHAI) , INC (CN) | 2022-12-08 | — | — | WO | disclosed |