Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.51 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.51 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.51 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7182433 | 0.86 | HTR2A (0.60) | GAAHTR2CHTR2BABCC9ABCC8 | |
| SCHEMBL775608 | 0.86 | HTR2C (0.59) | GAAHTR2CHTR2BABCC9ABCC8 | |
| SCHEMBL777135 | 0.84 | HTR6 (0.61) | GAAHTR2CHTR2BABCC9ABCC8 | |
| SCHEMBL6151129 | 0.82 | GAA (0.67) | GAAABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL31038387 | 0.82 | GAA (0.67) | GAAABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8867135 | 0.81 | HTR6 (0.59) | HTR2CHTR2BABCC9ABCC8KCNJ11 | |
| SCHEMBL9459488 | 0.81 | HTR2C (0.53) | GAAHTR2CHTR2BABCC9ABCC8 | |
| SCHEMBL3446114 | 0.81 | ALDH1A1 (0.59) | GAAHTR2CHTR2BABCC9ABCC8 | |
| SCHEMBL4792586 | 0.80 | GAA (0.76) | GAAHTTL3MBTL1MEN1KMT2A | |
| SCHEMBL4205906 | 0.79 | HTR2C (0.54) | GAAHTR2CHTR2BABCC9ABCC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220324866-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2022-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220324866-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | DGKG, DGKB, DGKK | GAA 2227/4885HTR2C 3776/4885HTR2B 3990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.