SCHEMBL2472218

SCHEMBL2472218

C=CCC1(C(=O)OC)CCOCC1

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
PKM P14618 1/20 0.36
CYP4F2 P78329 1/20 0.36
CYP4A11 Q02928 1/20 0.36
LMNA P02545 2/20 0.32
POLB P06746 2/20 0.32
MAPT P10636 1/20 0.32
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
RECQL P46063 1/20 0.32
NPSR1 Q6W5P4 1/20 0.31
TSHR P16473 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18367224 0.90 CYP4F2 (0.34) CYP2C19CYP3A4CYP2C9PKMCYP4F2
SCHEMBL2473877 0.84 CYP3A4 (0.37) CYP2C19CYP3A4CYP2C9PKMCYP4F2
SCHEMBL25188768 0.84 CYP4F2 (0.50) CYP2C19CYP3A4CYP4F2CYP4A11LMNA
SCHEMBL2479396 0.83 CYP4F2 (0.41) CYP2C19CYP3A4CYP2C9PKMCYP4F2
SCHEMBL18367198 0.83 TSHR (0.38) CYP2C19CYP3A4CYP2C9LMNAPOLB
SCHEMBL2633828 0.82 CYP4F2 (0.49) CYP2C19CYP3A4CYP4F2CYP4A11LMNA
SCHEMBL34476313 0.82 CYP4F2 (0.49) CYP2C19CYP3A4CYP4F2CYP4A11LMNA
SCHEMBL356582 0.82 CYP4F2 (0.34) CYP4F2CYP4A11LMNAALDH1A1
SCHEMBL17443947 0.82 USP2 (0.36) CYP4F2CYP4A11RECQL
SCHEMBL34475902 0.81 CYP4F2 (0.39) CYP4F2CYP4A11NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026090509-A1 SPIRO HETEROCYCLIC CDK2 INHIBITORS ARCHITECT THERAPEUTICS, INC. (US) 2026-04-30 WO disclosed
EP-4684837-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE Temple University of the Commonwealth System of Higher Education (US) 2026-01-28 EP disclosed
US-20250282790-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE PRAEVENTIX, LLC 2025-09-11 US disclosed
EP-3541790-B1 3-(2-(4-PHENYLPIPERAZIN-1-YL)ETHYL)-2-OXA-8-AZASPIRO[4.5]DECAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS 5-HYDROXYTRYPTAMINE RECEPTOR 7 (5-HT7) MODULATORS FOR TREATING E.G. INFLAMMATORY BOWEL DISEASE, CIRCADIAN RHYTHM DISORDER OR DEPRESSION UNIV TEMPLE (US) 2025-09-03 EP disclosed
US-12338247-B2 Modulators of the 5-hydroxytryptamine receptor 7 and their method of use TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2025-06-24 US disclosed
CN-119977980-A Novel modulators of 5-hydroxytryptamine receptor 7 and methods of use thereof 英联邦高等教育系统坦普尔大学 2025-05-13 CN disclosed
WO-2025059027-A1 CYCLOPENTA[E]PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS MALT1 INHIBITORS SCHRÖDINGER, INC. (US) 2025-03-20 WO disclosed
CN-110177776-B Novel modulators of 5-hydroxytryptamine receptor 7 and methods of use thereof 英联邦高等教育系统坦普尔大学 2025-02-28 CN disclosed
US-20230112888-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE PRAEVENTIX, LLC 2023-04-13 US disclosed
US-11319327-B2 Modulators of the 5-hydroxytryptamine receptor 7 and their method of use Temple University—Of the Commonwealth System of Higher Education (US) 2022-05-03 US disclosed
US-20110251225-A1 SUBSTITUTED TETRAHYDROPYRAN SPIRO PYRROLIDINONE AND PIPERIDINONE, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI (FR) 2011-10-13 US disclosed
US-20110251225-A1 SUBSTITUTED TETRAHYDROPYRAN SPIRO PYRROLIDINONE AND PIPERIDINONE, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI (FR) 2011-10-13 US disclosed
US-20110251225-A1 SUBSTITUTED TETRAHYDROPYRAN SPIRO PYRROLIDINONE AND PIPERIDINONE, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI (FR) 2011-10-13 US disclosed
EP-2373659-A1 SUBSTITUTED TETRAHYDROPYRAN SPIRO PYRROLIDINONE AND PIPERIDINONE, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI (FR) 2011-10-12 EP disclosed
WO-2010065798-A1 SUBSTITUTED TETRAHYDROPYRAN SPIRO PYRROLIDINONE AND PIPERIDINONE, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2010-06-10 WO disclosed
WO-2010065798-A1 SUBSTITUTED TETRAHYDROPYRAN SPIRO PYRROLIDINONE AND PIPERIDINONE, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2010-06-10 WO disclosed
US-20080058365-A1 Fused heterocyclic compounds AMGEN INC. 2008-03-06 US disclosed
US-20080058365-A1 Fused heterocyclic compounds AMGEN INC. 2008-03-06 US disclosed
US-7253179-B2 Fused heterocyclic compounds AMGEN INC. (US) 2007-08-07 US disclosed
US-7253179-B2 Fused heterocyclic compounds AMGEN INC. (US) 2007-08-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250282790-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE HTR7, HTR5A, HTR6 CYP2C19 854/4885CYP3A4 1664/4885CYP2C9 2058/4885
US-20110251225-A1 SUBSTITUTED TETRAHYDROPYRAN SPIRO PYRROLIDINONE AND PIPERIDINONE, PREPARATION AND THERAPEUTIC USE THEREOF HRH3, HRH4, HRH1 CYP2C19 1621/4885CYP3A4 1931/4885CYP2C9 1458/4885
US-20230112888-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE HTR7, HTR5A, HTR6 CYP2C19 854/4885CYP3A4 1664/4885CYP2C9 2058/4885
US-20080058365-A1 Fused heterocyclic compounds GIPR, MC4R, GPR119 CYP2C19 1437/4885CYP3A4 2070/4885CYP2C9 2974/4885
US-11319327-B2 Modulators of the 5-hydroxytryptamine receptor 7 and their method of use HTR7, HTR6, HTR5A CYP2C19 998/4885CYP3A4 1739/4885CYP2C9 2200/4885
US-12338247-B2 Modulators of the 5-hydroxytryptamine receptor 7 and their method of use HTR7, HTR6, HTR5A CYP2C19 998/4885CYP3A4 1739/4885CYP2C9 2200/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.