SCHEMBL24722688

SCHEMBL24722688

Cc1cnc2c(c1)CCC(CCN=O)C(=O)N2

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 4/20 0.33
DRD2 P14416 1/20 0.32
DRD1 P21728 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24722687 0.88 CRBN (0.34) CRBNDRD2DRD1
SCHEMBL24722690 0.78 SMYD3 (0.33) CRBNDRD2DRD1
SCHEMBL24723535 0.75 SMYD3 (0.36) CRBNDRD2DRD1
SCHEMBL6368447 0.68 CRBN (0.51) CRBN
SCHEMBL24722707 0.68 HTT (0.34) CRBN
SCHEMBL25704837 0.68 TSHR (0.38) CRBN
SCHEMBL6466846 0.67 NNMT (0.39) CRBN
SCHEMBL24722686 0.66
SCHEMBL24722682 0.66 CRBN (0.43) CRBN
SCHEMBL23938133 0.64 NNMT (0.41) DRD2DRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022187329-A1 FABI INHIBITORS FOR GRAM-NEGATIVE PATHOGENS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2022-09-09 WO disclosed