Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL693038 | 0.85 | POLB (0.40) | DRD2SLC6A2SLC6A4HTR2AKMT2A | |
| SCHEMBL2018650 | 0.85 | KDM4E (0.46) | DRD2SLC6A2SLC6A4HTR2AKMT2A | |
| SCHEMBL691897 | 0.82 | HTR2A (0.49) | DRD2SLC6A2SLC6A4HTR2AKMT2A | |
| SCHEMBL693333 | 0.80 | HTT (0.43) | KMT2ALMNAMEN1CYP3A4KDM4E | |
| SCHEMBL24722746 | 0.78 | NPSR1 (0.33) | HTR2AHTR2CHTR2B | |
| SCHEMBL24722876 | 0.78 | NPSR1 (0.33) | HTR2AHTR2CHTR2B | |
| SCHEMBL24722793 | 0.77 | HTR2C (0.50) | HTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL11830107 | 0.73 | DRD2 (0.41) | DRD2SLC6A2SLC6A4HTR2AHTR2C | |
| SCHEMBL24723423 | 0.71 | KDM4E (0.32) | HTR2AKMT2AHTR2CHTR2BKDM4E | |
| SCHEMBL24722751 | 0.71 | HRH3 (0.35) | HTR2AHTR2CHTR2BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022166920-A1 | PYRROLOPYRIDAZINE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2022-08-11 | — | — | WO | disclosed |