Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 7/20 | 0.42 |
| ▸ | NOS3 | P29474 | 6/20 | 0.42 |
| ▸ | REN | P00797 | 7/20 | 0.42 |
| ▸ | NOS1 | P29475 | 5/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
| ▸ | GABRE | P78334 | 1/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.37 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22063592 | 0.79 | REN (0.47) | NOS2NOS3RENNOS1GABRP | |
| SCHEMBL22062890 | 0.76 | NOS2 (0.42) | NOS2NOS3RENNOS1GABRP | |
| SCHEMBL1143077 | 0.74 | NOS2 (0.44) | NOS2NOS3RENNOS1BACE1 | |
| SCHEMBL30930705 | 0.74 | NOS2 (0.44) | NOS2NOS3RENNOS1BACE1 | |
| SCHEMBL22062839 | 0.72 | REN (0.41) | NOS2NOS3RENNOS1GABRP | |
| SCHEMBL25724674 | 0.69 | REN (0.39) | NOS2NOS3RENNOS1GABRP | |
| SCHEMBL9696133 | 0.68 | NOS3 (0.54) | NOS2NOS3RENNOS1GABRP | |
| SCHEMBL21610059 | 0.68 | KDM4E (0.42) | NOS2NOS3RENGABRPGABRD | |
| SCHEMBL23735858 | 0.68 | NOS2 (0.39) | NOS2NOS3RENNOS1GABRP | |
| SCHEMBL7742241 | 0.68 | NOS2 (0.48) | NOS2NOS3RENNOS1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131271-A1 | PYRROLE FUSED-RING PYRAZOLE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2023-07-13 | — | — | WO | disclosed |
| WO-2022166920-A1 | PYRROLOPYRIDAZINE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2022-08-11 | — | — | WO | disclosed |