Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14712982 | 0.86 | — | — | |
| SCHEMBL23153417 | 0.81 | ALDH1A1 (0.37) | HSD11B1ALDH1A1SIGMAR1DPP4DPP9 | |
| SCHEMBL11892671 | 0.80 | ALDH1A1 (0.52) | ALDH1A1SIGMAR1L3MBTL1MEN1KMT2A | |
| SCHEMBL24723677 | 0.79 | ACHE (0.41) | HSD11B1DPP4DPP9ESR2 | |
| SCHEMBL2697372 | 0.79 | HSD11B1 (0.36) | HSD11B1ALDH1A1ESR2 | |
| SCHEMBL13744934 | 0.79 | ALDH1A1 (0.40) | HSD11B1ALDH1A1SIGMAR1L3MBTL1MEN1 | |
| SCHEMBL2596647 | 0.79 | HSD11B1 (0.36) | HSD11B1ALDH1A1ESR2 | |
| SCHEMBL24723357 | 0.79 | ACHE (0.41) | HSD11B1DPP4DPP9ESR2 | |
| SCHEMBL6392070 | 0.78 | ALDH1A1 (0.55) | ALDH1A1SIGMAR1L3MBTL1MEN1KMT2A | |
| SCHEMBL21592409 | 0.77 | HSD11B1 (0.35) | HSD11B1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023083282-A1 | FUSED RING COMPOUND AS HPK1 INHIBITOR | 微境生物医药科技(上海)有限公司 | 2023-05-19 | — | — | WO | disclosed |
| WO-2022166920-A1 | PYRROLOPYRIDAZINE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2022-08-11 | — | — | WO | disclosed |