SCHEMBL24724

SCHEMBL24724

O=C(NO)C1(NS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)CCOCC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 20/20 1.00
MMP13 P45452 20/20 1.00
MMP2 P08253 2/20 0.79
MMP3 P08254 2/20 0.79
MMP9 P14780 2/20 0.79
MMP8 P22894 2/20 0.79
MMP14 P50281 2/20 0.79
MMP12 P39900 1/20 0.79
MMP7 P09237 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7208603 0.93 MMP1 (1.00) MMP1MMP13MMP2MMP3MMP9
SCHEMBL6956661 0.92 MMP1 (0.84) MMP1MMP13MMP2MMP3MMP9
SCHEMBL6949842 0.89 MMP1 (1.00) MMP1MMP13MMP2MMP3MMP9
SCHEMBL6957079 0.89 MMP1 (0.80) MMP1MMP13MMP2MMP3MMP9
SCHEMBL25304 0.88 MMP1 (1.00) MMP1MMP13MMP2MMP3MMP9
SCHEMBL14188830 0.88 MMP1 (0.83) MMP1MMP13MMP2MMP3MMP9
SCHEMBL12076423 0.88 MMP1 (0.79) MMP1MMP13MMP2MMP3MMP9
SCHEMBL6951011 0.87 MMP1 (1.00) MMP1MMP13MMP2MMP3MMP9
SCHEMBL24550 0.87 MMP1 (1.00) MMP1MMP13MMP2MMP3MMP9
SCHEMBL136290 0.87 MMP1 (1.00) MMP1MMP13MMP2MMP3MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 695 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1070058-B1 (4-ARYLSULFONYLAMINO)-TETRAHYDROPYRAN-4-CARBOXYLIC ACID HYDROXAMIDES PFIZER PROD INC (US) 2003-05-02 EP claimed
EP-1070058-A1 (4-ARYLSULFONYLAMINO)-TETRAHYDROPYRAN-4-CARBOXYLIC ACID HYDROXAMIDES Pfizer Products Inc. (US) 2001-01-24 EP claimed
US-6087392-A A METALLOPROTEINASE INHIBITORS FOR INHIBITING MAMMALIAN REPROLYSIN PFIZER INC. (US) 2000-07-11 US claimed
WO-1999052889-A1 (4-ARYLSULFONYLAMINO)-TETRAHYDROPYRAN-4-CARBOXYLIC ACID HYDROXAMIDES PFIZER PRODUCTS INC. (US) 1999-10-21 WO claimed
US-20250320217-A1 SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES AS PROTEIN KINASE INHIBITORS SUMITOMO PHARMA AMERICA INC (US) 2025-10-16 US disclosed
US-20250214963-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH PFIZER INC. 2025-07-03 US disclosed
US-20250129085-A1 SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES AS PROTEIN KINASE INHIBITORS SUMITOMO PHARMA AMERICA INC (US) 2025-04-24 US disclosed
US-12037404-B2 Human monoclonal antibodies against EphA4 and their use THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2024-07-16 US disclosed
EP-2534153-B2 SALTS AND POLYMORPHS OF 8-FLUORO-2-{4-[(METHYLAMINO}METHYL]PHENYL}-1,3,4,5-TETRAHYDRO-6H-AZEPINO[5,4,3-CD]INDOL-6-ONE PFIZER (US) 2024-05-22 EP disclosed
US-20240109862-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH PFIZER INC. 2024-04-04 US disclosed
US-20240083855-A1 JAK2 AND ALK2 INHIBITORS AND METHODS FOR THEIR USE SUMITOMO PHARMA AMERICA, INC. (US) 2024-03-14 US disclosed
EP-3590932-B1 JAK2 AND ALK2 INHIBITORS AND METHODS FOR THEIR USE SUMITOMO PHARMA ONCOLOGY INC (US) 2023-05-03 EP disclosed
US-6258824-B1 TREATMENT OF HYPERPROLIFERATIVE DISEASES, SUCH AS CANCERS, IN MAMMALS. THIS INVENTION ALSO RELATES TO A PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS. PFIZER INC. 2001-07-10 US disclosed
EP-1106612-A1 Quinoline derivatives useful for inhibiting farnesyl protein transferase Pfizer Products Inc. (US) 2001-06-13 EP disclosed
WO-2001040217-A1 NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS PFIZER PRODUCTS INC. (US) 2001-06-07 WO disclosed
WO-2001034574-A1 STABLE POLYMORPH OF N-(3-ETHYNYLPHENYLAMINO)-6,7-BIS(2-METHOXYETHOXY)-4-QUINAZOLINAMINE HYDROCHLORIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF OSI PHARMACEUTICALS, INC. (US) 2001-05-17 WO disclosed
EP-1070058-A1 (4-ARYLSULFONYLAMINO)-TETRAHYDROPYRAN-4-CARBOXYLIC ACID HYDROXAMIDES Pfizer Products Inc. (US) 2001-01-24 EP disclosed
WO-2000047574-A1 HETEROARYL-SUBSTITUTED QUINOLIN-2-ONE DERIVATIVES USEFUL AS ANTICANCER AGENTS PFIZER PRODUCTS INC. (US) 2000-08-17 WO disclosed
US-6087392-A A METALLOPROTEINASE INHIBITORS FOR INHIBITING MAMMALIAN REPROLYSIN PFIZER INC. (US) 2000-07-11 US disclosed
WO-1999052889-A1 (4-ARYLSULFONYLAMINO)-TETRAHYDROPYRAN-4-CARBOXYLIC ACID HYDROXAMIDES PFIZER PRODUCTS INC. (US) 1999-10-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250214963-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH GPR119, INSR, LYAR MMP1 3955/4885MMP13 4604/4885MMP2 4086/4885
US-20240083855-A1 JAK2 AND ALK2 INHIBITORS AND METHODS FOR THEIR USE ALK, JAK2, JAK1 MMP1 2298/4885MMP13 2440/4885MMP2 2512/4885
US-20250129085-A1 SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES AS PROTEIN KINASE INHIBITORS PIM1, PIM2, PIM3 MMP1 2061/4885MMP13 4280/4885MMP2 3813/4885
US-20240109862-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH GPR119, INSR, LYAR MMP1 3955/4885MMP13 4604/4885MMP2 4086/4885
US-20250320217-A1 SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES AS PROTEIN KINASE INHIBITORS PIM1, PIM2, PIM3 MMP1 2061/4885MMP13 4280/4885MMP2 3813/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.