Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.39 |
| ▸ | PRLHR | P49683 | 3/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22746796 | 0.89 | MTHFD2 (0.44) | P2RX7HSD11B1PGRMTHFD2TMEM97 | |
| SCHEMBL24496466 | 0.83 | P2RX7 (0.38) | P2RX7HSD11B1ABL1BCRPGR | |
| SCHEMBL29504784 | 0.83 | HPGD (0.44) | P2RX7HSD11B1PGRMTHFD2SIGMAR1 | |
| SCHEMBL22717861 | 0.83 | HPGD (0.44) | P2RX7HSD11B1PGRMTHFD2SIGMAR1 | |
| SCHEMBL9971920 | 0.76 | HSD11B1 (0.53) | P2RX7HSD11B1ABL1BCRPGR | |
| SCHEMBL24775629 | 0.76 | PRLHR (0.39) | P2RX7HSD11B1ABL1BCRPGR | |
| SCHEMBL22718069 | 0.75 | HPGD (0.44) | P2RX7HSD11B1PGRMTHFD2 | |
| SCHEMBL29504776 | 0.75 | HPGD (0.44) | P2RX7HSD11B1PGRMTHFD2 | |
| SCHEMBL29220558 | 0.73 | SIGMAR1 (0.36) | MTHFD2TMEM97SIGMAR1 | |
| SCHEMBL22718828 | 0.73 | HPGD (0.48) | P2RX7HSD11B1PGRMTHFD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022253259-A1 | FUSED HETEROCYCLIC DERIVATIVES | Janssen Sciences Ireland Unlimited Company (IE) | 2022-12-08 | — | — | WO | disclosed |