Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.52 |
| ▸ | NTSR2 | O95665 | 1/20 | 0.45 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | ENPEP | Q07075 | 5/20 | 0.44 |
| ▸ | MDM4 | O15151 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25083892 | 0.92 | BACE1 (0.49) | BACE1NTSR2NTSR1GRIN2DGRIN3B | |
| SCHEMBL24725395 | 0.92 | BACE1 (0.48) | BACE1NTSR2NTSR1GRIN2DGRIN3B | |
| SCHEMBL24725396 | 0.92 | BACE1 (0.47) | BACE1NTSR2NTSR1GRIN2DGRIN3B | |
| SCHEMBL24724812 | 0.91 | BACE1 (0.47) | BACE1NTSR2NTSR1GRIN2DGRIN3B | |
| SCHEMBL29646562 | 0.90 | BACE1 (0.58) | BACE1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29556987 | 0.89 | NTSR2 (0.51) | BACE1NTSR2NTSR1GRIN2DGRIN3B | |
| SCHEMBL29679591 | 0.89 | NTSR2 (0.52) | BACE1NTSR2NTSR1GRIN2DGRIN3B | |
| SCHEMBL30657221 | 0.88 | ENPEP (0.50) | BACE1NTSR2NTSR1GRIN2DGRIN3B | |
| SCHEMBL30163257 | 0.87 | ENPEP (0.51) | BACE1ENPEPMDM4MDM2CTSD | |
| SCHEMBL10375379 | 0.87 | ENPEP (0.54) | BACE1NTSR2NTSR1ENPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023028338-A2 | MANNOSE 6-PHOSPHATE OR ASGPR RECEPTOR BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2023-03-02 | — | — | WO | disclosed |
| WO-2022235699-A2 | POTENT ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF IMMUNOGLOBULINS AND OTHER PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |