SCHEMBL24726533

SCHEMBL24726533

O=C(O)c1cccc([C@H]2CCCN2)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMO O15229 1/20 0.58
CHRNB2 P17787 2/20 0.47
CHRNA7 P36544 2/20 0.47
CHRNA4 P43681 2/20 0.47
PRMT5 O14744 1/20 0.46
WDR77 Q9BQA1 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.43
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
CYP2D6 P10635 2/20 0.43
CYP2C19 P33261 2/20 0.43
POLB P06746 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2A6 P11509 1/20 0.43
CYP2C9 P11712 1/20 0.43
PRKAB2 O43741 1/20 0.42
PRKAG1 P54619 1/20 0.42
PRKAA2 P54646 1/20 0.42
PRKAA1 Q13131 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29285106 1.00 KMO (0.58) KMOCHRNB2CHRNA7CHRNA4PRMT5
SCHEMBL10311097 0.86 CHRNB2 (0.46) KMOCHRNB2CHRNA7CHRNA4PRMT5
SCHEMBL839470 0.82 PRMT5 (0.45) CHRNB2CHRNA7CHRNA4PRMT5WDR77
SCHEMBL10311104 0.82 PRMT5 (0.45) CHRNB2CHRNA7CHRNA4PRMT5WDR77
Hydrochloric Acid SCHEMBL10277298 0.81 PRMT5 (0.45) CHRNB2CHRNA7CHRNA4PRMT5WDR77
SCHEMBL28580499 0.80 PRKAB2 (0.48) CHRNB2CHRNA7CHRNA4L3MBTL1MEN1
SCHEMBL14839512 0.78 PRKACA (0.48) KMOMEN1KMT2ASMN1; SMN2CYP1A2
SCHEMBL8220141 0.77 MBTD1 (0.49) PRMT5WDR77L3MBTL1MEN1KMT2A
SCHEMBL19465286 0.77 KMO (0.69) KMOKMT2A
SCHEMBL4280772 0.77 CHRNB2 (0.53) CHRNB2CHRNA7CHRNA4L3MBTL1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022234965-A1 HETEROARYL DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT 주식회사 보로노이 2022-11-10 WO disclosed