Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PER2 | O15055 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.30 |
| ▸ | CHRNG | P07510 | 1/20 | 0.30 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | CHRND | Q07001 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25595155 | 0.89 | ALDH1A1 (0.33) | P2RX7ALDH1A1PER2KDM4ECYP1A2 | |
| SCHEMBL22571215 | 0.80 | HRH3 (0.39) | P2RX7ALDH1A1KDM4ECYP1A2GLA | |
| SCHEMBL11363827 | 0.75 | GLO1 (0.38) | ALDH1A1PER2HPGDTSHRHRH3 | |
| SCHEMBL22864661 | 0.74 | ALOX15 (0.34) | P2RX7KDM4ECYP1A2CYP3A4CHRNA1 | |
| SCHEMBL24729534 | 0.69 | CHRNA1 (0.30) | CHRNA1CHRNGCHRNB1CHRNB2CHRNA4 | |
| SCHEMBL25118591 | 0.69 | ALOX15 (0.36) | P2RX7CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL11921171 | 0.69 | HRH3 (0.37) | ALDH1A1KDM4ECYP1A2GLACYP3A4 | |
| SCHEMBL23759636 | 0.68 | HRH3 (0.46) | ALDH1A1KDM4EHRH3 | |
| SCHEMBL21220787 | 0.64 | BRD4 (0.42) | ALDH1A1KDM4ECYP1A2CYP3A4HPGD | |
| SCHEMBL22017463 | 0.64 | ALDH1A1 (0.37) | P2RX7ALDH1A1PER2KDM4EHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220389037-A1 | HPK1 INHIBITORS AND USES THEREOF | REGOR PHARMACEUTICALS, INC. | 2022-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220389037-A1 | HPK1 INHIBITORS AND USES THEREOF | HIPK1, SIK1, PGK1 | P2RX7 4241/4885ALDH1A1 3740/4885PER2 3112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.