Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 8/20 | 0.37 |
| ▸ | GRM5 | P41594 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24729570 | 0.86 | SMN1; SMN2 (0.41) | METTL3KLKB1GRM5SMN1; SMN2NPC1 | |
| SCHEMBL29958329 | 0.84 | SMN1; SMN2 (0.42) | METTL3KLKB1GRM5SMN1; SMN2NPC1 | |
| SCHEMBL24738256 | 0.84 | KLKB1 (0.38) | METTL3KLKB1GRM5SMN1; SMN2NPC1 | |
| SCHEMBL24729668 | 0.84 | METTL3 (0.39) | METTL3KLKB1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29141754 | 0.82 | METTL3 (0.41) | METTL3KLKB1KDM4E | |
| SCHEMBL24738257 | 0.82 | METTL3 (0.39) | METTL3KLKB1 | |
| SCHEMBL24729661 | 0.80 | SMN1; SMN2 (0.46) | METTL3KLKB1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29958412 | 0.79 | KLKB1 (0.36) | METTL3KLKB1 | |
| SCHEMBL27033615 | 0.79 | KLKB1 (0.36) | METTL3KLKB1 | |
| SCHEMBL27030423 | 0.79 | METTL3 (0.37) | METTL3KLKB1GRM5SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117396473-A | Imidazopyridinyl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-12 | — | — | CN | disclosed |
| CN-117396474-A | Plasma kallikrein inhibitors | 武田药品工业株式会社 | 2024-01-12 | — | — | CN | disclosed |
| WO-2022197755-A1 | IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |