Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 7/20 | 0.41 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24729570 | 0.84 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4ENPC1RAB9AMETTL3 | |
| SCHEMBL29958329 | 0.80 | SMN1; SMN2 (0.42) | SMN1; SMN2KDM4ENPC1RAB9AMETTL3 | |
| SCHEMBL24729569 | 0.80 | METTL3 (0.39) | SMN1; SMN2KDM4ENPC1RAB9AMETTL3 | |
| SCHEMBL29303098 | 0.77 | KLKB1 (0.40) | SMN1; SMN2KDM4ENPC1RAB9AMETTL3 | |
| SCHEMBL24729668 | 0.77 | METTL3 (0.39) | SMN1; SMN2KDM4ENPC1RAB9AMETTL3 | |
| SCHEMBL29303097 | 0.76 | KLKB1 (0.39) | METTL3KLKB1 | |
| SCHEMBL24738256 | 0.76 | KLKB1 (0.38) | SMN1; SMN2KDM4ENPC1RAB9AMETTL3 | |
| SCHEMBL30711687 | 0.76 | KLKB1 (0.39) | METTL3KLKB1 | |
| SCHEMBL27030423 | 0.75 | METTL3 (0.37) | SMN1; SMN2KDM4ENPC1RAB9AMETTL3 | |
| SCHEMBL29141754 | 0.74 | METTL3 (0.41) | KDM4EMETTL3KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022197755-A1 | IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |