SCHEMBL2472984

SCHEMBL2472984

COc1ccc(NC(=O)OC(C)(C)C)c(NC(=O)c2ccc(C(CCN(C)C)NC(=O)Nc3ccc4c(c3)CCC4)cc2)c1

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 13/20 0.48
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
NPC1 O15118 2/20 0.42
RAB9A P51151 2/20 0.42
POLB P06746 1/20 0.42
ALDH1A1 P00352 1/20 0.41
CASP3 P42574 1/20 0.41
SENP7 Q9BQF6 1/20 0.41
MCHR1 Q99705 1/20 0.41
OPRM1 P35372 1/20 0.40
OPRD1 P41143 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3834371 0.91 UTS2R (0.43) UTS2RKMT2ANPC1RAB9AALDH1A1
SCHEMBL2478122 0.87 UTS2R (0.42) UTS2RMEN1KMT2ANPC1RAB9A
SCHEMBL2474154 0.87 UTS2R (0.52) UTS2RMEN1KMT2ANPC1RAB9A
SCHEMBL2476917 0.84 UTS2R (0.61) UTS2R
SCHEMBL2477989 0.84 KMT2A (0.45) UTS2RMEN1KMT2ANPC1RAB9A
SCHEMBL2493868 0.81 NPC1 (0.42) MEN1KMT2ANPC1RAB9AALDH1A1
SCHEMBL2477559 0.81 NPC1 (0.42) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL4392859 0.81 ALDH1A1 (0.42) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL2476207 0.81 NPC1 (0.41) MEN1KMT2ANPC1RAB9AALDH1A1
SCHEMBL2478436 0.79 NPC1 (0.41) MEN1KMT2ANPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8076332-B2 N- (2-aminophenyl) benzamide derivative having urea structure SANTEN PHARMACEUTICAL CO., LTD. (JP) 2011-12-13 US disclosed
EP-2107052-B1 NOVEL N-(2-AMINOPHENYL)BENZAMIDE DERIVATIVE HAVING AN UREA STRUCTURE SANTEN PHARMACEUTICAL CO LTD (JP) 2011-10-12 EP disclosed
US-20090306077-A1 NOVEL N- (2-AMINOPHENYL) BENZAMIDE DERIVATIVE HAVING UREA STRUCTURE SANTEN PHARMACEUTICAL CO., LTD. (JP) 2009-12-10 US disclosed
EP-2107052-A1 NOVEL N-(2-AMINOPHENYL)BENZAMIDE DERIVATIVE HAVING AN UREA STRUCTURE Santen Pharmaceutical Co., Ltd (JP) 2009-10-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090306077-A1 NOVEL N- (2-AMINOPHENYL) BENZAMIDE DERIVATIVE HAVING UREA STRUCTURE UACA, SLC14A1, ARG2 UTS2R 11/4885MEN1 4006/4885KMT2A 1888/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.