Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.40 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.39 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13594085 | 1.00 | P2RX7 (0.42) | P2RX7SLC6A9NPFFR1NPFFR2LMNA | |
| SCHEMBL13594062 | 0.87 | P2RX7 (0.39) | P2RX7SLC6A9LMNAATRKCNA3 | |
| SCHEMBL13594316 | 0.84 | P2RX7 (0.40) | P2RX7NPFFR1NPFFR2LMNAATR | |
| SCHEMBL2470148 | 0.83 | SLC6A9 (0.46) | P2RX7SLC6A9LMNAATRALDH1A1 | |
| SCHEMBL2468682 | 0.82 | SLC6A9 (0.51) | P2RX7SLC6A9LMNAATR | |
| SCHEMBL2469437 | 0.82 | LMNA (0.49) | P2RX7LMNAATRALDH1A1POLB | |
| SCHEMBL2491434 | 0.81 | OPRD1 (0.48) | P2RX7KCNA3MEN1KMT2A | |
| SCHEMBL2467928 | 0.80 | SLC6A9 (0.51) | P2RX7SLC6A9LMNAATRMAPK1 | |
| SCHEMBL2495626 | 0.80 | CYP2D6 (0.47) | P2RX7LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL2496825 | 0.80 | SLC6A9 (0.43) | P2RX7SLC6A9LMNAKCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2371366-A1 | Heterocyclo inhibitors of potassium channel function | Bristol-Myers Squibb Company (US) | 2011-10-05 | — | — | EP | disclosed |
| EP-1501467-A4 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2009-08-19 | — | — | EP | disclosed |
| EP-1501467-A2 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | Bristol-Myers Squibb Company (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003088908-A2 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-10-30 | — | — | WO | disclosed |