Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLRMT | O00411 | 1/20 | 0.36 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24737136 | 1.00 | POLRMT (0.36) | POLRMTDOT1LPDE2A | |
| SCHEMBL25853155 | 0.89 | POLRMT (0.38) | POLRMTDOT1LPDE2A | |
| SCHEMBL25300989 | 0.89 | POLRMT (0.38) | POLRMTDOT1LPDE2A | |
| SCHEMBL25254465 | 0.89 | POLRMT (0.38) | POLRMTDOT1LPDE2A | |
| SCHEMBL19101790 | 0.86 | POLRMT (0.36) | POLRMTDOT1LPDE2A | |
| SCHEMBL16701318 | 0.84 | POLRMT (0.35) | POLRMT | |
| SCHEMBL24736798 | 0.82 | POLRMT (0.34) | POLRMTDOT1L | |
| SCHEMBL20960029 | 0.80 | POLRMT (0.35) | POLRMTDOT1L | |
| SCHEMBL24736751 | 0.79 | TNK2 (0.32) | POLRMT | |
| SCHEMBL25852259 | 0.77 | POLRMT (0.36) | POLRMTDOT1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11697666-B2 | Methods of preparing carbanucleosides using amides | GILEAD SCIENCES, INC. (US) | 2023-07-11 | — | — | US | disclosed |
| WO-2022221514-A1 | METHODS OF PREPARING CARBANUCLEOSIDES USING AMIDES | GILEAD SCIENCES, INC. (US) | 2022-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11697666-B2 | Methods of preparing carbanucleosides using amides | NCL, DUT, POLN | POLRMT 89/4885DOT1L 449/4885PDE2A 3245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.