Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLRMT | O00411 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.35 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25300989 | 0.90 | POLRMT (0.38) | POLRMTTNK2DOT1LRIPK1PDE2A | |
| SCHEMBL25853155 | 0.90 | POLRMT (0.38) | POLRMTTNK2DOT1LRIPK1PDE2A | |
| SCHEMBL25254465 | 0.90 | POLRMT (0.38) | POLRMTTNK2DOT1LRIPK1PDE2A | |
| SCHEMBL24736765 | 0.86 | POLRMT (0.36) | POLRMTDOT1LPDE2A | |
| SCHEMBL24737136 | 0.86 | POLRMT (0.36) | POLRMTDOT1LPDE2A | |
| SCHEMBL16701318 | 0.85 | POLRMT (0.35) | POLRMT | |
| SCHEMBL18371669 | 0.84 | POLRMT (0.35) | POLRMTTNK2DOT1LRIPK1 | |
| SCHEMBL16708502 | 0.84 | POLRMT (0.35) | POLRMTTNK2DOT1LRIPK1 | |
| SCHEMBL16710421 | 0.81 | POLRMT (0.36) | POLRMTDOT1L | |
| SCHEMBL20960029 | 0.79 | POLRMT (0.35) | POLRMTTNK2DOT1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10377761-B2 | Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections | GILEAD SCIENCES, INC. (US) | 2019-08-13 | — | — | US | disclosed |
| US-20190055253-A1 | PYRROLO[1,2-f][1,2,4]TRIAZINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | GILEAD SCIENCES, INC. | 2019-02-21 | — | — | US | disclosed |
| US-20180016280-A1 | PYRROLO[1,2-f][1,2,4]TRIAZINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | GILEAD SCIENCES, INC. | 2018-01-18 | — | — | US | disclosed |
| US-9701682-B2 | Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections | GILEAD SCIENCES, INC. (US) | 2017-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180016280-A1 | PYRROLO[1,2-f][1,2,4]TRIAZINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | SYNJ1, SARS1, SYNJ2 | POLRMT 306/4885TNK2 2505/4885DOT1L 882/4885 |
| US-10377761-B2 | Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections | SYNJ1, SARS1, SYNJ2 | POLRMT 306/4885TNK2 2505/4885DOT1L 882/4885 |
| US-20190055253-A1 | PYRROLO[1,2-f][1,2,4]TRIAZINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | SYNJ1, SARS1, SYNJ2 | POLRMT 306/4885TNK2 2505/4885DOT1L 882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.