Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ebastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.82 |
| ▸ | HTR2A | P28223 | 3/20 | 0.82 |
| ▸ | DRD2 | P14416 | 2/20 | 0.82 |
| ▸ | HTR1A | P08908 | 2/20 | 0.82 |
| ▸ | DRD1 | P21728 | 2/20 | 0.82 |
| ▸ | DRD4 | P21917 | 2/20 | 0.82 |
| ▸ | HTR2C | P28335 | 2/20 | 0.82 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.82 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.82 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.82 |
| ▸ | NPC1 | O15118 | 1/20 | 0.82 |
| ▸ | MLNR | O43193 | 1/20 | 0.82 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.82 |
| ▸ | EGFR | P00533 | 1/20 | 0.82 |
| ▸ | LMNA | P02545 | 1/20 | 0.82 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.82 |
| ▸ | FYN | P06241 | 1/20 | 0.82 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.82 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.82 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ebastine SCHEMBL25202686 | 0.95 | DRD2 (0.88) | HTR2ADRD2HTR1ADRD1DRD4 | |
| Carebastine SCHEMBL26674085 | 0.94 | HTR2A (0.71) | HTR2ADRD2HTR1ADRD1DRD4 | |
| Ebastine SCHEMBL25228349 | 0.92 | DRD2 (0.93) | HTR2ADRD2HTR1ADRD1DRD4 | |
| Ebastine SCHEMBL18467 | 0.90 | ADRA1D (1.00) | HTR2ADRD2HTR1ADRD1DRD4 | |
| Ebastine SCHEMBL25205252 | 0.90 | ADRA1D (0.98) | HTR2ADRD2HTR1ADRD1DRD4 | |
| Ebastine SCHEMBL2546560 | 0.89 | ADRA1D (0.96) | HTR2ADRD2HTR1ADRD1DRD4 | |
| SCHEMBL12197484 | 0.88 | CHRM2 (0.94) | HTR2ADRD2HTR1ADRD1DRD4 | |
| SCHEMBL1362953 | 0.88 | ADRA1D (0.94) | HTR2ADRD2HTR1ADRD1DRD4 | |
| SCHEMBL12142398 | 0.88 | ADRA1A (0.79) | HTR2ADRD2HTR1ADRD1DRD4 | |
| SCHEMBL26674078 | 0.87 | DRD2 (0.69) | HTR2ADRD2HTR1ADRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121099-A2 | PROCESS FOR THE PREPARATION OF 1-[4-(1,1-DIMETHYLETHYL)PHENYL]-4-[4-(DIPHENYLMETHOXY)-1-PIPERIDINYL]-1-BUTANONE AND ACID ADDITION SALTS THEREOF | AREVIPHARMA GMBH (DE) | 2011-10-06 | — | — | WO | disclosed |
| EP-2371817-A1 | Process for the preparation of 1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone and acid addition salts thereof | Arevipharma GmbH (DE) | 2011-10-05 | — | — | EP | disclosed |