Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 4/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | GRN | P28799 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12376582 | 0.77 | BAZ2B (0.53) | BAZ2BGRM5CA2PLK1EPHX2 | |
| SCHEMBL3550941 | 0.72 | BAZ2B (0.51) | BAZ2BGRM5CA2HDAC6HDAC2 | |
| SCHEMBL19886206 | 0.70 | MLYCD (0.52) | GRM5MLYCDHCAR3HCAR2CLK1 | |
| SCHEMBL20442952 | 0.68 | GRM5 (0.44) | GRM5MLYCDGRNSORT1 | |
| SCHEMBL24571392 | 0.68 | ALDH1A1 (0.50) | HCAR3 | |
| SCHEMBL12017909 | 0.67 | BAZ2B (0.53) | BAZ2BGRM5PLK1HCAR3HDAC6 | |
| SCHEMBL20224123 | 0.67 | GRM5 (0.51) | GRM5MLYCDHCAR3GRNSORT1 | |
| SCHEMBL24571828 | 0.67 | HCAR3 (0.42) | GRM5MLYCDCA2HCAR3HDAC6 | |
| SCHEMBL23029668 | 0.66 | SMN1; SMN2 (0.41) | — | |
| SCHEMBL7962334 | 0.66 | BAZ2B (0.74) | BAZ2BGRM5PLK1HDAC6HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022253283-A1 | PROTEIN KINASE DEGRADANT AND USE THEREOF | 中国科学院上海有机化学研究所 | 2022-12-08 | — | — | WO | disclosed |